Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone deacetylase | 0.0208 | 0.4027 | 0.4027 |
Giardia lamblia | Histone deacetylase | 0.0231 | 0.4959 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0356 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0231 | 0.4959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1365 | 0.1365 |
Echinococcus granulosus | histone deacetylase 6 | 0.0208 | 0.4027 | 0.611 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231 | 0.4959 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231 | 0.4959 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0231 | 0.4959 | 0.5 |
Onchocerca volvulus | 0.0172 | 0.2562 | 0.5 | |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0231 | 0.4959 | 0.5 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0172 | 0.2562 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0231 | 0.4959 | 0.1561 |
Echinococcus granulosus | histone deacetylase 6 | 0.0214 | 0.4268 | 0.7117 |
Echinococcus granulosus | histone deacetylase 1 | 0.0231 | 0.4959 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0208 | 0.4027 | 0.611 |
Schistosoma mansoni | histone deacetylase | 0.0231 | 0.4959 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0208 | 0.4027 | 0.4027 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0231 | 0.4959 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0231 | 0.4959 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0208 | 0.4027 | 0.611 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0231 | 0.4959 | 0.4959 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.4844 | 0.9521 |
Onchocerca volvulus | 0.0172 | 0.2562 | 0.5 | |
Onchocerca volvulus | 0.0172 | 0.2562 | 0.5 | |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0231 | 0.4959 | 0.1561 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.4844 | 0.4844 |
Brugia malayi | hypothetical protein | 0.0228 | 0.4844 | 0.1369 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0356 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0231 | 0.4959 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0231 | 0.4959 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0208 | 0.4027 | 0.611 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0231 | 0.4959 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0231 | 0.4959 | 0.1561 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0208 | 0.4027 | 0.611 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0214 | 0.4268 | 0.7117 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231 | 0.4959 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0231 | 0.4959 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.4844 | 0.9521 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0231 | 0.4959 | 0.1561 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0208 | 0.4027 | 0.611 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231 | 0.4959 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0231 | 0.4959 | 0.1561 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0214 | 0.4268 | 0.7117 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.4959 | 0.4959 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2956 | 0.2956 |
Leishmania major | histone deacetylase, putative | 0.0231 | 0.4959 | 0.1561 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0231 | 0.4959 | 0.4959 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0208 | 0.4027 | 0.611 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0231 | 0.4959 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0231 | 0.4959 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231 | 0.4959 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0231 | 0.4959 | 0.1561 |
Echinococcus granulosus | histone deacetylase | 0.0208 | 0.4027 | 0.611 |
Leishmania major | histone deacetylase, putative | 0.0231 | 0.4959 | 0.1561 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0231 | 0.4959 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0208 | 0.4027 | 0.611 |
Schistosoma mansoni | histone deacetylase | 0.0231 | 0.4959 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0208 | 0.4027 | 0.611 |
Onchocerca volvulus | 0.0172 | 0.2562 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Cleavage of supercoiled DNA plasmid pBR322 after 2 days | ChEMBL. | 16870443 |
Activity (binding) | 0 | Cleavage of supercoiled DNA plasmid pBR322 after 2 days in presence of dithiothreitol | ChEMBL. | 16870443 |
Activity (binding) | = 18 % | Conversion of type 1 supercoiled DNA to type 2 nicked DNA in presence of dithiothreitol | ChEMBL. | 16870443 |
Activity (binding) | = 44 % | Conversion of type 1 supercoiled DNA to type 2 nicked DNA | ChEMBL. | 16870443 |
Activity (binding) | = 64 % | Conversion of type 1 supercoiled DNA to type 2 nicked DNA in presence of dithiothreitol relative to Kinamycin D | ChEMBL. | 16870443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.