Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.0052 | 0.3698 | 0.3698 |
Onchocerca volvulus | 0.0019 | 0.0138 | 0.5 | |
Echinococcus granulosus | nmda type glutamate receptor | 0.0055 | 0.3967 | 0.3882 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0055 | 0.3967 | 0.3967 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0052 | 0.3698 | 0.361 |
Echinococcus multilocularis | acetylcholinesterase | 0.0111 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0019 | 0.0138 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0111 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0019 | 0.0138 | 0.0138 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0019 | 0.0138 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0111 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0019 | 0.0138 | 0.0138 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0019 | 0.0138 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.007 | 0.5565 | 0.5503 |
Onchocerca volvulus | 0.0019 | 0.0138 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0111 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0.0138 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0111 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0019 | 0.0138 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0111 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0111 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0.0138 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0019 | 0.0138 | 0.0138 |
Onchocerca volvulus | 0.0019 | 0.0138 | 0.5 | |
Schistosoma mansoni | glutamate receptor NMDA | 0.006 | 0.4491 | 0.4414 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0019 | 0.0138 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0019 | 0.0138 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0019 | 0.0138 | 0.0138 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.007 | 0.5565 | 0.5565 |
Loa Loa (eye worm) | carboxylesterase | 0.0111 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.12 | Relative potency of the compound using frog skin bioassay system | ChEMBL. | 7452698 |
Potency (functional) | = 0.4 | Relative potency of the compound using melanoma adenylate cyclase bioassay system from S-91 melanoma tumors grown in DBA/2J mice | ChEMBL. | 7452698 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.