Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) | 0.0740666 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.00058494 | 0 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.00178514 | 0.0163333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00167066 | 0.0147753 | 0.904616 |
Schistosoma mansoni | cell adhesion molecule | 0.00167066 | 0.0147753 | 1 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0449675 | 0.603995 | 1 |
Trypanosoma cruzi | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.00058494 | 0 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.00167066 | 0.0147753 | 0.0244627 |
Echinococcus granulosus | Immunoglobulin | 0.00125992 | 0.00918564 | 0.0152081 |
Onchocerca volvulus | 0.00058494 | 0 | 0.5 | |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.00058494 | 0 | 0.5 |
Plasmodium vivax | unspecified product | 0.00058494 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.00178514 | 0.0163333 | 1 |
Plasmodium vivax | adrenodoxin reductase, putative | 0.00058494 | 0 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.00167066 | 0.0147753 | 0.0244627 |
Plasmodium vivax | unspecified product | 0.00058494 | 0 | 0.5 |
Plasmodium vivax | unspecified product | 0.00058494 | 0 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.00125992 | 0.00918564 | 0.621686 |
Loa Loa (eye worm) | hypothetical protein | 0.00167066 | 0.0147753 | 0.904616 |
Brugia malayi | hypothetical protein | 0.00125992 | 0.00918564 | 0.562388 |
Mycobacterium ulcerans | UDP-galactopyranose mutase Glf | 0.0740666 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.00167066 | 0.0147753 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.00125992 | 0.00918564 | 0.621686 |
Echinococcus granulosus | twitchin | 0.00125992 | 0.00918564 | 0.0152081 |
Schistosoma mansoni | vesicular amine transporter | 0.00125992 | 0.00918564 | 0.621686 |
Echinococcus multilocularis | Immunoglobulin | 0.00125992 | 0.00918564 | 0.621686 |
Loa Loa (eye worm) | hypothetical protein | 0.00125992 | 0.00918564 | 0.562388 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.00058494 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.00058494 | 0 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.00125992 | 0.00918564 | 0.562388 |
Leishmania major | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.00058494 | 0 | 0.5 |
Trypanosoma cruzi | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.00058494 | 0 | 0.5 |
Echinococcus granulosus | defective proboscis extension response | 0.00125992 | 0.00918564 | 0.0152081 |
Mycobacterium tuberculosis | UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) | 0.0740666 | 1 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.00058494 | 0 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.00125992 | 0.00918564 | 0.621686 |
Loa Loa (eye worm) | hypothetical protein | 0.00125992 | 0.00918564 | 0.562388 |
Echinococcus multilocularis | neuroglian | 0.00125992 | 0.00918564 | 0.621686 |
Echinococcus granulosus | neuroglian | 0.00125992 | 0.00918564 | 0.0152081 |
Toxoplasma gondii | hypothetical protein | 0.00058494 | 0 | 0.5 |
Onchocerca volvulus | 0.00058494 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.00125992 | 0.00918564 | 0.562388 |
Loa Loa (eye worm) | hypothetical protein | 0.00125992 | 0.00918564 | 0.562388 |
Toxoplasma gondii | prenylcysteine oxidase | 0.00058494 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00125992 | 0.00918564 | 0.562388 |
Schistosoma mansoni | nephrin | 0.00125992 | 0.00918564 | 0.621686 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.00125992 | 0.00918564 | 0.621686 |
Loa Loa (eye worm) | hypothetical protein | 0.00167066 | 0.0147753 | 0.904616 |
Loa Loa (eye worm) | hypothetical protein | 0.00125992 | 0.00918564 | 0.562388 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.00125992 | 0.00918564 | 0.562388 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.00058494 | 0 | 0.5 |
Toxoplasma gondii | electron transfer flavoprotein-ubiquinone oxidoreductase | 0.00058494 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 32 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 8 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 1 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 0.5 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | 0 % | In vitro cytotoxic activity against mouse peritonealmacrophages at a concentration 32 microM. | ChEMBL. | 11356101 |
Cytotoxicity (functional) | 0 % | In vitro cytotoxic activity against mouse peritoneal macrophages at a concentration 8 microM; Non-toxic | ChEMBL. | 11356101 |
Cytotoxicity (functional) | 0 % | In vitro cytotoxic activity against mouse peritoneal macrophages at a concentration 2 microM; Non-toxic | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 32 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 8 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 1 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 0.5 microM | ChEMBL. | 11356101 |
IC50 (functional) | = 266.2 nM | In vitro growth inhibition of P. falciparum FcB1R strain | ChEMBL. | 11356101 |
IC50 (functional) | = 266.2 nM | In vitro growth inhibition of P. falciparum FcB1R strain | ChEMBL. | 11356101 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11356101 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.