Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | No references |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.1143 | 0.2349 | 0.2312 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0335 | 0.0275 | 0.0275 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4123 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3008 | 0.7135 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0272 | 0.0114 | 0.0066 |
Echinococcus multilocularis | thymidylate synthase | 0.1143 | 0.2349 | 0.2349 |
Brugia malayi | hypothetical protein | 0.0544 | 0.081 | 0.0766 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1143 | 0.2349 | 0.2349 |
Echinococcus granulosus | dihydrofolate reductase | 0.4123 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3008 | 0.7135 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0335 | 0.0275 | 0.0275 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4123 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.4123 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1143 | 0.2349 | 0.2349 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.031 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.0275 | 0.0163 |
Schistosoma mansoni | dihydrofolate reductase | 0.4123 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.4123 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0544 | 0.081 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3008 | 0.7135 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4123 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.4123 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3008 | 0.7135 | 0.5 |
Onchocerca volvulus | 0.1143 | 0.2349 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3008 | 0.7135 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1143 | 0.2349 | 0.1674 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4123 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3008 | 0.7135 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.1143 | 0.2349 | 0.2261 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10 uM | Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement. | ChEMBL. | No reference |
Ki (binding) | > 10 uM | Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement. | ChEMBL. | No reference |
Ki (binding) | > 10 uM | Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement. | ChEMBL. | No reference |
Ki (binding) | > 10 uM | Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.