Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | somatostatin receptor 5 | Starlite/ChEMBL | References |
Homo sapiens | somatostatin receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | somatostatin receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | somatostatin receptor 4 | Starlite/ChEMBL | References |
Homo sapiens | somatostatin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 2 | 369 aa | 411 aa | 18.7 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 5 | 364 aa | 392 aa | 19.4 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 4 | 388 aa | 372 aa | 20.7 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 1 | 391 aa | 368 aa | 21.5 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 190 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 5. | ChEMBL. | 11405660 |
IC50 (binding) | = 190 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 5. | ChEMBL. | 11405660 |
IC50 (binding) | = 213 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 2. | ChEMBL. | 11405660 |
IC50 (binding) | = 213 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 2. | ChEMBL. | 11405660 |
IC50 (binding) | = 267 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 4. | ChEMBL. | 11405660 |
IC50 (binding) | = 267 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 4. | ChEMBL. | 11405660 |
IC50 (binding) | = 273 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 3. | ChEMBL. | 11405660 |
IC50 (binding) | = 273 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 3. | ChEMBL. | 11405660 |
IC50 (binding) | = 309 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 1. | ChEMBL. | 11405660 |
IC50 (binding) | = 309 nM | Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 1. | ChEMBL. | 11405660 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.