Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0586 | 0.2072 | 0.2244 | |
Echinococcus multilocularis | adenylate cyclase type IX | 0.0934 | 0.526 | 1 |
Onchocerca volvulus | 0.0618 | 0.2366 | 0.2561 | |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0618 | 0.2366 | 0.4497 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 0.2366 | 0.2366 |
Brugia malayi | Adenylyl cyclase protein | 0.0618 | 0.2366 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1336 | 0.8943 | 0.8943 |
Echinococcus granulosus | adenylate cyclase type IX | 0.0934 | 0.526 | 1 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0618 | 0.2366 | 0.2561 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1368 | 0.9237 | 1 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0618 | 0.2366 | 0.4497 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0359 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED300 (ADMET) | = 10.6 ug kg-1 | Effective dose required to reduce Uosm from hydropenic levels to plasma osmolality levels (300 mosm/kg of H2O) | ChEMBL. | 2960813 |
K bind (binding) | = 21 nM | Affinity towards vasopressin receptor in porcine renal medullary membrane using [3H]-LVP | ChEMBL. | 2960813 |
Ki (binding) | = 7.8 nM | Compound was evaluated for the inhibition constant for inhibition of 8-lysine-vasopressin stimulated adenylate cyclase of pig kidney medullary membrane | ChEMBL. | 2960813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.