Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.6664 | 1 |
Treponema pallidum | adenosine deaminase | 0.0256 | 0.6664 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0256 | 0.6664 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0256 | 0.6664 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0256 | 0.6664 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0298 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0256 | 0.6664 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0256 | 0.6664 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0298 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0298 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0256 | 0.6664 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0256 | 0.6664 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0256 | 0.6664 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0298 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0298 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0298 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0256 | 0.6664 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0256 | 0.6664 | 0.5 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0256 | 0.6664 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0298 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0256 | 0.6664 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0256 | 0.6664 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0256 | 0.6664 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 2.408 | Calculated partition coefficient (clogP) | ChEMBL. | 12657285 |
MIC (functional) | = 3.52 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus 01A0758 | ChEMBL. | 12657285 |
MIC (functional) | > 50 ug ml-1 | In vitro antibacterial activity against Escherichia coli 51A0150 | ChEMBL. | 12657285 |
MIC (functional) | > 50 ug ml-1 | In vitro antibacterial activity against Pasteurella multocida 59A0067 | ChEMBL. | 12657285 |
MIC (functional) | > 50 ug ml-1 | In vitro antibacterial activity against Escherichia coli 51A0150 | ChEMBL. | 12657285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.