Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1455 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0884 | 0.5246 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0942 | 0.5732 | 1 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.088 | 0.521 | 0.909 |
Onchocerca volvulus | 0.0699 | 0.3704 | 0.5 | |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0386 | 0.1098 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0884 | 0.5246 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1455 | 1 | 0.5 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.088 | 0.521 | 0.909 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0386 | 0.1098 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0942 | 0.5732 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 2.554 | Calculated partition coefficient (clogP) | ChEMBL. | 12657285 |
MIC (functional) | = 3.13 ug ml-1 | In vitro antibacterial activity against Pasteurella multocida 59A0067 | ChEMBL. | 12657285 |
MIC (functional) | = 12.5 ug ml-1 | In vitro antibacterial activity against Escherichia coli 51A0150 | ChEMBL. | 12657285 |
MIC (functional) | = 12.5 ug ml-1 | In vitro antibacterial activity against Escherichia coli 51A0150 | ChEMBL. | 12657285 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus 01A0758 | ChEMBL. | 12657285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.