Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | uridine phosphorylase | 0.2352 | 0.5 | 0.5 |
Mycobacterium leprae | probable uridine phosphorylase | 0.2352 | 0.5 | 0.5 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.2352 | 0.5 | 0.5 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.2352 | 0.5 | 0.5 |
Loa Loa (eye worm) | uridine phosphorylase | 0.2352 | 0.5 | 0.5 |
Schistosoma mansoni | uridine phosphorylase | 0.2352 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MED (functional) | = 1.85 mg kg-1 | Minimum effective dose for immunostimulant activity in mice was determined | ChEMBL. | No reference |
MED (functional) | = 1.85 mg kg-1 | Minimum effective dose for immunostimulant activity in mice was determined | ChEMBL. | No reference |
Solubility | < 6 mg ml-1 | Solubility of the compound was determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.