TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.413 | Formula: C18H19NO4S
H donors: 2 H acceptors: 3 LogP: 2.21 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O[C@H]1[C@H](NC(=O)c2ccccc2)c2sc(cc2OC1(C)C)C(=O)C
InChi: 1S/C18H19NO4S/c1-10(20)13-9-12-15(24-13)14(16(21)18(2,3)23-12)19-17(22)11-7-5-4-6-8-11/h4-9,14,16,21H,1-3H3,(H,19,22)/t14-,16+/m1/s1
InChiKey: OHJJQHBTRJYLNM-ZBFHGGJFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0653	0.1097
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0653	1
Onchocerca volvulus		0.0036	0.0653	0.0154
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus multilocularis	sex peptide receptor	0.0036	0.0653	1
Onchocerca volvulus		0.0036	0.0653	0.0154
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.016	0.5953	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0653	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0224	0.8681	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Brugia malayi	neuropeptide F receptor	0.0036	0.0653	0.0752
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0506	0.7756
Echinococcus granulosus	neuropeptide FF receptor 2	0.0036	0.0653	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0653	0.0752
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0653	1
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0653	0.1097
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0653	1
Schistosoma mansoni	amine GPCR	0.0036	0.0653	0.1097
Brugia malayi	G-protein coupled receptor	0.0036	0.0653	0.0752
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0653	1
Echinococcus granulosus	allatostatin A receptor	0.0036	0.0653	1
Echinococcus multilocularis	neuropeptide s receptor	0.0036	0.0653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Loa Loa (eye worm)	TYRA-2 protein	0.0036	0.0653	0.0752
Brugia malayi	Serotonin receptor	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0036	0.0653	0.0752
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0653	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0653	1
Echinococcus multilocularis	serotonin receptor	0.0036	0.0653	1
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0653	0.1097
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0653	0.1097
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0653	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0036	0.0653	1
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus multilocularis	orexin receptor type 2	0.0036	0.0653	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0036	0.0653	0.0752
Brugia malayi	Melatonin receptor type 1A	0.0036	0.0653	0.0752
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	neuropeptide receptor A26	0.0036	0.0653	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0653	0.0752
Echinococcus multilocularis	somatostatin receptor	0.0036	0.0653	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0036	0.0653	1
Brugia malayi	follicle stimulating hormone receptor	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	amine GPCR	0.0036	0.0653	0.1097
Schistosoma mansoni	hypothetical protein	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0653	1
Onchocerca volvulus		0.0036	0.0653	0.0154
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus granulosus	7TM GPCR rhodopsin	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	growth hormone secretagogue receptor	0.0036	0.0653	0.1097
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0653	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0036	0.0653	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0506	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0506	0.0851
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0036	0.0653	0.0752
Brugia malayi	Dopamine receptor protein 2	0.0036	0.0653	0.0752
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0036	0.0653	0.0752
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0653	0.1097
Schistosoma mansoni	myosin xvIII	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0036	0.0653	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0653	1
Echinococcus multilocularis	allatostatin A receptor	0.0036	0.0653	1
Brugia malayi	AKH receptor	0.0036	0.0653	0.0752
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0653	0.1097
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0036	0.0653	1
Echinococcus granulosus	neuropeptide s receptor	0.0036	0.0653	1
Brugia malayi	putative neuropeptide receptor	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0653	0.1097
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0653	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0653	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0036	0.0653	0.1097
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0653	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0506	0.0851
Brugia malayi	G-protein coupled receptor	0.0036	0.0653	0.0752
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0653	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0506	0.0851
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0653	0.0752
Schistosoma mansoni	neuropeptide f receptor 76f	0.0036	0.0653	0.1097
Brugia malayi	Pre-SET motif family protein	0.0224	0.8681	1
Brugia malayi	neuropeptide F receptor	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Brugia malayi	Pre-SET motif family protein	0.0032	0.0506	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	serotonin receptor	0.0036	0.0653	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0653	1
Brugia malayi	Serotonin receptor	0.0036	0.0653	0.0752
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0147	0.5385	1
Brugia malayi	GnHR receptor homolog	0.0036	0.0653	0.0752
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0653	1
Brugia malayi	Dopamine receptor protein 1	0.0036	0.0653	0.0752
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0036	0.0653	0.0752
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0036	0.0653	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0653	0.1097
Brugia malayi	Dopamine receptor	0.0036	0.0653	0.0752
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0036	0.0653	0.1097
Schistosoma mansoni	opsin-like receptor	0.0036	0.0653	0.1097
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0653	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0036	0.0653	1
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0653	0.1097
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0653	1
Schistosoma mansoni	opsin-like receptor	0.0036	0.0653	0.1097
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0036	0.0653	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0653	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0036	0.0653	0.0752
Echinococcus granulosus	serotonin receptor	0.0036	0.0653	1
Echinococcus multilocularis	g-protein coupled receptor	0.0036	0.0653	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0653	0.1097
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0653	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0036	0.0653	1
Brugia malayi	sulfakinin receptor protein	0.0036	0.0653	0.0752
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0653	0.1097
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0036	0.0653	0.1097
Brugia malayi	larval opioid receptor	0.0036	0.0653	0.0752
Schistosoma mansoni	opsin-like receptor	0.0036	0.0653	0.1097
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0036	0.0653	0.0752
Echinococcus multilocularis	dro:myosuppressin receptor	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0	0.5
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Echinococcus granulosus	neuropeptide receptor A26	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0653	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0036	0.0653	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0036	0.0653	0.1097
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0036	0.0653	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0	0.5
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Echinococcus granulosus	sex peptide receptor	0.0036	0.0653	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0653	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0653	1
Trichomonas vaginalis	set domain proteins, putative	0.0255	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	somatostatin receptor	0.0036	0.0653	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0	0.5
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0506	0.7756
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0036	0.0653	0.1097
Plasmodium vivax	SET domain protein, putative	0.0032	0.0506	1
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0653	0.0752
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0036	0.0653	0.0752
Echinococcus granulosus	fmrfamide receptor	0.0036	0.0653	1
Echinococcus granulosus	G protein coupled receptor 139	0.0036	0.0653	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0036	0.0653	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0506	0.7756
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Onchocerca volvulus		0.0036	0.0653	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0506	0.0583
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0653	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.016	0.5953	0.6857
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0506	0.0851
Brugia malayi	G protein-coupled receptor F59B2.13	0.0036	0.0653	0.0752
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0036	0.0653	0.1097
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0036	0.0653	1
Brugia malayi	ORL1-like opioid receptor	0.0036	0.0653	0.0752
Onchocerca volvulus		0.0036	0.0653	0.0154
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0653	1
Brugia malayi	G protein-coupled receptor	0.0036	0.0653	0.0752
Schistosoma mansoni	amine GPCR	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Brugia malayi	RE15519p	0.0036	0.0653	0.0752
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0036	0.0653	0.1097
Schistosoma mansoni	amine GPCR	0.0036	0.0653	0.1097
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0036	0.0653	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0653	0.1097
Echinococcus granulosus	orexin receptor type 2	0.0036	0.0653	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0653	1
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0653	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0036	0.0653	0.0752
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0036	0.0653	0.0154
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0456	0.6984
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0036	0.0653	0.1097
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0653	1
Schistosoma mansoni	d-amino acid oxidase	0.016	0.5953	1
Echinococcus granulosus	hypothetical protein	0.0036	0.0653	1
Onchocerca volvulus		0.0036	0.0653	0.0154
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0036	0.0653	0.1097
Onchocerca volvulus		0.0036	0.0653	0.0154
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0036	0.0653	1
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.016	0.5953	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0653	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0653	0.1097
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0653	1
Onchocerca volvulus		0.0036	0.0653	0.0154
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0653	1
Schistosoma mansoni	histamine h1 receptor	0.0036	0.0653	0.1097
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0653	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0653	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0036	0.0653	0.0752
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0036	0.0653	1
Schistosoma mansoni	amine GPCR	0.0036	0.0653	0.1097
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0036	0.0653	0.0752
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0653	0.1097
Schistosoma mansoni	hypothetical protein	0.0036	0.0653	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0036	0.0653	1
Onchocerca volvulus		0.0036	0.0653	0.0154
Brugia malayi	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0653	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0653	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0653	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0036	0.0653	0.0154
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Schistosoma mansoni	adenoreceptor	0.0036	0.0653	0.1097
Brugia malayi	putative neuropeptide receptor NPR1	0.0036	0.0653	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752
Echinococcus granulosus	dro:myosuppressin receptor	0.0036	0.0653	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0653	0.0752

Activities

Activity type	Activity value	Assay description	Source	Reference
Change MAP (functional)	NT 55 %	Maximal change in mean arterial blood pressure comparing MAP immediately prior to and up to 240 min after oral dose in rat	ChEMBL.	No reference
ED30 (functional)	= 0.2 mg kg-1	Dose to produce 30% reduction in mean arterial pressure in rat when administered perorally	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL31551

Bibliographic References

No literature references available for this target.

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Detailed information for compound 40107