Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Prostaglandin E synthase | 0.1783 | 1 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1783 | 1 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.1783 | 1 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.0667 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.0667 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0059 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0059 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1783 | 1 | 1 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.1783 | 1 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0059 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.1783 | 1 | 0.5 | |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1783 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.32 nM | Inhibition of human plasma renin. | ChEMBL. | 1995887 |
T1/2 (ADMET) | = 69 min | Duration in minutes required for a 50% return of the blood pressure from its maximum effect in human renin infused rat after intravenous administration | ChEMBL. | 1995887 |
T1/2 (ADMET) | = 81 min | Duration in minutes required for a 50% return of the blood pressure from its maximum effect in human renin infused rat after oral administration | ChEMBL. | 1995887 |
T1/2 (ADMET) | > 120 min | Hypotensive response in human renin infused rat model after oral administration ithrough 0.25%(carboxymethyl)cellulose in water vehicle | ChEMBL. | 1995887 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.