Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0233 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.033 | 0.7204 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0233 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0233 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.27 nM | Inhibition of human glucocorticoid receptor | ChEMBL. | 15293993 |
Ki (binding) | = 0.27 nM | Inhibition of human glucocorticoid receptor | ChEMBL. | 15293993 |
Ki (binding) | = 0.53 nM | Inhibition of human progesterone receptor | ChEMBL. | 15293993 |
Ki (binding) | = 0.53 nM | Inhibition of human progesterone receptor | ChEMBL. | 15293993 |
Ki (binding) | = 8.9 nM | Inhibition of human androgen receptor | ChEMBL. | 15293993 |
Ki (binding) | = 8.9 nM | Inhibition of human androgen receptor | ChEMBL. | 15293993 |
Ki (binding) | = 10 nM | Inhibition of human Estrogen receptor alpha | ChEMBL. | 15293993 |
Ki (binding) | = 10 nM | Inhibition of human Estrogen receptor alpha | ChEMBL. | 15293993 |
Ki (binding) | = 30 nM | Inhibition of human Estrogen receptor beta | ChEMBL. | 15293993 |
Ki (binding) | = 30 nM | Inhibition of human Estrogen receptor beta | ChEMBL. | 15293993 |
Ki (functional) | = 37 nM | Inhibition of glucocorticoid receptor dependent alkaline phosphatase activity | ChEMBL. | 15293993 |
Ki (functional) | = 37 nM | Inhibition of glucocorticoid receptor dependent alkaline phosphatase activity | ChEMBL. | 15293993 |
Ki (binding) | = 140 nM | Inhibition of human Mineralocorticoid receptor | ChEMBL. | 15293993 |
Ki (binding) | = 140 nM | Inhibition of human Mineralocorticoid receptor | ChEMBL. | 15293993 |
Ki (functional) | = 160 nM | Inhibition of glucocorticoid receptor mediated tyrosine amino transferase activity | ChEMBL. | 15293993 |
Ki (functional) | = 160 nM | Inhibition of glucocorticoid receptor mediated tyrosine amino transferase activity | ChEMBL. | 15293993 |
Ki (binding) | > 1250 nM | Inhibition of human Thyroid hormone receptor alpha | ChEMBL. | 15293993 |
Ki (binding) | > 1250 nM | Inhibition of human Thyroid hormone receptor alpha | ChEMBL. | 15293993 |
Ki (binding) | > 2250 nM | Inhibition of human Thyroid hormone receptor beta | ChEMBL. | 15293993 |
Ki (binding) | > 2250 nM | Inhibition of human Thyroid hormone receptor beta | ChEMBL. | 15293993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.