TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1244.63 | Formula: C62H111N14O12
H donors: 5 H acceptors: 12 LogP: 8.03 Rotable bonds: 17
Rule of 5 violations (Lipinski): 3
SMILES: [NH-]=[N+]=NCCC/C=C(\C(C1C(=O)NC(CC)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)O)/C
InChi: 1S/C62H110N14O12/c1-24-43-58(84)70(17)33-48(77)71(18)44(29-34(2)3)55(81)68-49(38(10)11)61(87)72(19)45(30-35(4)5)54(80)65-41(15)53(79)66-42(16)57(83)73(20)46(31-36(6)7)59(85)74(21)47(32-37(8)9)60(86)75(22)50(39(12)13)62(88)76(23)51(56(82)67-43)52(78)40(14)27-25-26-28-64-69-63/h27,34-39,41-47,49-52,78H,24-26,28-33H2,1-23H3,(H,65,80)(H,66,79)(H,67,82)(H,68,81)/b40-27-
InChiKey: QNUFDBCOJMNDKS-DPVRLLIJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0086	0.4131	0.4131
Loa Loa (eye worm)	G-protein coupled receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	ecdysone induced protein 78C	0.0162	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0161	0.9852	0.9852
Onchocerca volvulus		0.0161	0.9852	0.9775
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0086	0.4131	0.4131
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0077	0.3428	0.3428
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0162	1	1
Echinococcus granulosus	somatostatin receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0162	1	1
Schistosoma mansoni	histamine h1 receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0086	0.4131	0.4131
Echinococcus multilocularis	g protein coupled receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor E75	0.0077	0.3428	0.3428
Echinococcus multilocularis	nuclear receptor nhr 48	0.0077	0.3428	0.3428
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Brugia malayi	neuropeptide F receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Brugia malayi	GnHR receptor homolog	0.0161	0.9852	0.9852
Brugia malayi	G-protein coupled receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	g protein coupled receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	neuropeptide receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0162	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0161	0.9852	0.9852
Brugia malayi	Serotonin receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Onchocerca volvulus	Protein ultraspiracle homolog	0.0162	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	neuropeptide receptor A26	0.0161	0.9852	0.9852
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0162	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0086	0.4131	0.4131
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0161	0.9852	0.9852
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0077	0.3428	0.3428
Brugia malayi	tailless protein	0.0077	0.3428	0.3428
Onchocerca volvulus		0.0161	0.9852	0.9775
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0161	0.9852	0.9852
Brugia malayi	Melatonin receptor type 1A	0.0161	0.9852	0.9852
Schistosoma mansoni	neuropeptide receptor	0.0161	0.9852	0.9852
Onchocerca volvulus		0.0161	0.9852	0.9775
Echinococcus granulosus	7TM GPCR rhodopsin	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0162	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	tm gpcr rhodopsin	0.0161	0.9852	0.9852
Echinococcus granulosus	biogenic amine 5HT receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0077	0.3428	0.3428
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0162	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0162	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus multilocularis	sex peptide receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0162	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0162	1	1
Brugia malayi	RE15519p	0.0161	0.9852	0.9852
Brugia malayi	AKH receptor	0.0161	0.9852	0.9852
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0161	0.9852	0.9775
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0162	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0161	0.9852	0.9852
Schistosoma mansoni	amine GPCR	0.0161	0.9852	0.9852
Brugia malayi	nuclear hormone receptor	0.0162	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0086	0.4131	0.4131
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.011	0.5984	0.5984
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus multilocularis	dro:myosuppressin receptor	0.0161	0.9852	0.9852
Brugia malayi	nuclear hormone receptor	0.0077	0.3428	0.3428
Echinococcus granulosus	fmrfamide receptor	0.0161	0.9852	0.9852
Onchocerca volvulus		0.0161	0.9852	0.9775
Brugia malayi	nuclear hormone receptor family member odr-7	0.0077	0.3428	0.3428
Brugia malayi	hypothetical protein	0.0086	0.4131	0.4131
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	serotonin receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	neuropeptides capa receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Brugia malayi	hypothetical protein	0.0086	0.4131	0.4131
Loa Loa (eye worm)	steroid hormone receptor	0.0162	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0161	0.9852	0.9852
Schistosoma mansoni	biogenic amine receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	neuropeptide Y receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	biogenic amine receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0161	0.9852	0.9852
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0077	0.3428	0.3428
Onchocerca volvulus		0.0161	0.9852	0.9775
Schistosoma mansoni	neuropeptide receptor	0.0161	0.9852	0.9852
Brugia malayi	photoreceptor-specific nuclear receptor	0.0162	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0162	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0161	0.9852	0.9775
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0077	0.3428	0.3428
Schistosoma mansoni	biogenic amine receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0077	0.3428	0.3428
Schistosoma mansoni	myosin xvIII	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0162	1	1
Echinococcus granulosus	neuropeptide receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	somatostatin receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0161	0.9852	0.9852
Echinococcus multilocularis	neuropeptides capa receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Brugia malayi	nuclear receptor RXR	0.0086	0.4131	0.4131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0162	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor-like 1	0.0086	0.4131	0.4131
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0161	0.9852	0.9852
Brugia malayi	G-protein coupled receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Onchocerca volvulus		0.0161	0.9852	0.9775
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.011	0.5984	0.5984
Schistosoma mansoni	nuclear receptor	0.0077	0.3428	0.3428
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0162	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0162	1	1
Schistosoma mansoni	nuclear receptor	0.0077	0.3428	0.3428
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Echinococcus granulosus	7tm_1 domain containing protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0077	0.3428	0.3428
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0077	0.3428	0.3428
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Echinococcus granulosus	neuropeptide receptor	0.0161	0.9852	0.9852
Brugia malayi	nuclear receptor NHR-88	0.0077	0.3428	0.3428
Echinococcus granulosus	orexin receptor type 2	0.0161	0.9852	0.9852
Brugia malayi	hypothetical protein	0.0077	0.3428	0.3428
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0161	0.9852	0.9852
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0161	0.9852	0.9852
Schistosoma mansoni	zinc finger protein	0.0077	0.3428	0.3428
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0161	0.9852	0.9852
Echinococcus multilocularis	neuropeptide receptor A26	0.0161	0.9852	0.9852
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Echinococcus multilocularis	allatostatin A receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0162	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0162	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0162	1	1
Brugia malayi	Dopamine receptor protein 1	0.0161	0.9852	0.9852
Echinococcus multilocularis	fmrfamide receptor	0.0161	0.9852	0.9852
Brugia malayi	putative neuropeptide receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	serotonin receptor	0.0161	0.9852	0.9852
Brugia malayi	ORL1-like opioid receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	opsin-like receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0162	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0162	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0162	1	1
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Echinococcus granulosus	FTZ F1 alpha	0.0162	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.012	0.6758	0.6758
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	g protein coupled receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	neuropeptide receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Brugia malayi	Serotonin receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	thyroid hormone receptor	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Brugia malayi	follicle stimulating hormone receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0161	0.9852	0.9852
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Schistosoma mansoni	neuropeptide receptor	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0162	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor-like 1	0.0086	0.4131	0.4131
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Brugia malayi	G protein-coupled receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	amine GPCR	0.0161	0.9852	0.9852
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.543	0.5
Schistosoma mansoni	hypothetical protein	0.0161	0.9852	0.9852
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus multilocularis	neuropeptide Y receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0161	0.9852	0.9852
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0162	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0161	0.9852	0.9852
Brugia malayi	steroid hormone receptor	0.0162	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0161	0.9852	0.9852
Onchocerca volvulus		0.0161	0.9852	0.9775
Echinococcus granulosus	g-protein coupled receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	opsin-like receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Echinococcus granulosus	dro:myosuppressin receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0162	1	1
Brugia malayi	Dopamine receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	nuclear receptor nhr-48	0.0077	0.3428	0.3428
Schistosoma mansoni	neuropeptide receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.011	0.5984	0.5984
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0161	0.9852	0.9852
Schistosoma mansoni	amine GPCR	0.0161	0.9852	0.9852
Echinococcus granulosus	neuropeptides capa receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0077	0.3428	0.3428
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0162	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0077	0.3428	0.3428
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0161	0.9852	0.9852
Brugia malayi	putative neuropeptide receptor NPR1	0.0161	0.9852	0.9852
Schistosoma mansoni	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	neuropeptide F-like receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	TYRA-2 protein	0.0161	0.9852	0.9852
Brugia malayi	hypothetical protein	0.0077	0.3428	0.3428
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0161	0.9852	0.9852
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0077	0.3428	0.3428
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0161	0.9852	0.9852
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0162	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0162	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	sex peptide receptor	0.0161	0.9852	0.9852
Brugia malayi	orphan nuclear receptor NR2E1	0.0077	0.3428	0.3428
Schistosoma mansoni	adenoreceptor	0.0161	0.9852	0.9852
Echinococcus granulosus	allatostatin A receptor	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0162	1	1
Schistosoma mansoni	amine GPCR	0.0161	0.9852	0.9852
Brugia malayi	larval opioid receptor	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor-like 1	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus multilocularis	neuropeptide Y receptor	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0162	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Brugia malayi	nuclear receptor NHR-67	0.0077	0.3428	0.3428
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	opsin-like receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	g protein coupled receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	g protein coupled receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	amine GPCR	0.0161	0.9852	0.9852
Echinococcus granulosus	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0162	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0161	0.9852	0.9852
Brugia malayi	Dopamine receptor protein 2	0.0161	0.9852	0.9852
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0086	0.4131	0.4131
Echinococcus multilocularis	orexin receptor type 2	0.0161	0.9852	0.9852
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0161	0.9852	0.9852
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0162	1	1
Brugia malayi	ecdysone receptor	0.0077	0.3428	0.3428
Echinococcus granulosus	biogenic amine 5HT receptor	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0162	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0161	0.9852	0.9852
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0161	0.9852	0.9852
Loa Loa (eye worm)	neuropeptide F receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	hypothetical protein	0.0161	0.9852	0.9852
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.543	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0161	0.9852	0.9852
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0162	1	1
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus multilocularis	neuropeptide s receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0162	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0162	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0161	0.9852	0.9852
Schistosoma mansoni	voltage-gated potassium channel	0.012	0.6758	0.6758
Echinococcus granulosus	neuropeptide s receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	g-protein coupled receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0162	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0161	0.9852	0.9852
Onchocerca volvulus		0.0161	0.9852	0.9775
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	thyroid hormone receptor alpha	0.0077	0.3428	0.3428
Onchocerca volvulus		0.0161	0.9852	0.9775
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	G protein coupled receptor 139	0.0161	0.9852	0.9852
Echinococcus granulosus	neuropeptide FF receptor 2	0.0161	0.9852	0.9852
Echinococcus multilocularis	FTZ F1 alpha	0.0162	1	1
Brugia malayi	nuclear receptor NHR-88	0.0162	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0162	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0086	0.4131	0.4131
Schistosoma mansoni	coup transcription factor	0.0162	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Onchocerca volvulus	Bile acid receptor homolog	0.0162	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0077	0.3428	0.3428
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0162	1	1
Onchocerca volvulus		0.0161	0.9852	0.9775
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0077	0.3428	0.3428
Loa Loa (eye worm)	hypothetical protein	0.0086	0.4131	0.4131
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	retinoic acid receptor RXR	0.0162	1	1
Brugia malayi	nuclear receptor RXR	0.0077	0.3428	0.3428
Loa Loa (eye worm)	melatonin receptor type 1A	0.0161	0.9852	0.9852
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	DR-78	0.0077	0.3428	0.3428
Onchocerca volvulus		0.0161	0.9852	0.9775
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Brugia malayi	neuropeptide F receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0086	0.4131	0.4131
Onchocerca volvulus		0.0161	0.9852	0.9775
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus multilocularis	ecdysone induced protein 78C	0.0162	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0077	0.3428	0.3428
Schistosoma mansoni	RAR-like nuclear receptor	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	G-protein coupled receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3428	0.3428
Brugia malayi	sulfakinin receptor protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0161	0.9852	0.9852
Onchocerca volvulus		0.0161	0.9852	0.9775
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4871	0.4871
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0161	0.9852	0.9852
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0086	0.4131	0.4131
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0077	0.3428	0.3428
Onchocerca volvulus		0.0161	0.9852	0.9775
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0161	0.9852	0.9852
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0162	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0162	1	1
Onchocerca volvulus		0.0161	0.9852	0.9775
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0162	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Onchocerca volvulus		0.0162	1	1
Echinococcus multilocularis	serotonin receptor	0.0161	0.9852	0.9852
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0161	0.9852	0.9852
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0161	0.9852	0.9852
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0077	0.3428	0.3428
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0162	1	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0161	0.9852	0.9852
Schistosoma mansoni	thyroid hormone receptor	0.0162	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0077	0.3428	0.3428
Echinococcus multilocularis	G protein coupled receptor 139	0.0161	0.9852	0.9852
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0161	0.9852	0.9852
Schistosoma mansoni	nuclear hormone receptor	0.0077	0.3428	0.3428
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.011	0.5984	0.5984
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0162	1	1
Onchocerca volvulus		0.0161	0.9852	0.9775
Onchocerca volvulus		0.0161	0.9852	0.9775
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0162	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0161	0.9852	0.9852
Brugia malayi	hypothetical protein	0.0161	0.9852	0.9852
Brugia malayi	conserved hypotetical protein	0.0077	0.3428	0.3428
Brugia malayi	Nuclear hormone receptor E75	0.0077	0.3428	0.3428
Echinococcus granulosus	tm gpcr rhodopsin	0.0161	0.9852	0.9852
Echinococcus granulosus	nuclear receptor nhr 48	0.0077	0.3428	0.3428
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0161	0.9852	0.9852
Loa Loa (eye worm)	hypothetical protein	0.0161	0.9852	0.9852

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 7.98 uM	Effective concentration required for the lysis of Trypanosoma cruzi trypomastigotes in blood stream after 24 hours of treatment	ChEMBL.	15324878
IC50 (binding)	= 23.16 nM	Inhibition of Peptidyl-prolyl cis-trans isomerase Trypanosoma cruzi cyclophilin (CL Brener strain, p19)	ChEMBL.	15324878
IC50 (functional)	= 10.55 uM	Compound was tested for the inhibition of Trypanosoma cruzi epimastigote growth after 72 hours of treatment	ChEMBL.	15324878

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 408411

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 407235