Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2768 | 0.4976 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2768 | 0.4976 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0339 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0713 | 0.0766 | 0.0766 |
Chlamydia trachomatis | dihydrofolate reductase | 0.5221 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.5221 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.5221 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2768 | 0.4976 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.5221 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.5221 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.5221 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.5221 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.5221 | 1 | 1 |
Onchocerca volvulus | 0.0713 | 0.0766 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.0713 | 0.0766 | 0.0766 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2768 | 0.4976 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2768 | 0.4976 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2768 | 0.4976 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.5221 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 16.4 ug ml-1 | Inhibition of gram positive bacteria growth. | ChEMBL. | 2724308 |
MIC (functional) | = 100 ug ml-1 | Inhibition of gram positive (resistant) bacteria growth. | ChEMBL. | 2724308 |
MIC (functional) | > 200 ug ml-1 | Inhibition of gram negative bacteria growth. | ChEMBL. | 2724308 |
MIC (functional) | > 200 ug ml-1 | Inhibition of gram negative (resistant) growth. | ChEMBL. | 2724308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.