TDR Targets

Basic information

Technical information

TDR Targets ID: 410325
Name: 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-2-methyl- 1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxo cyclobuten-1-yl]amino]benzamide
MW: 411.451 | Formula: C22H25N3O5
H donors: 3 H acceptors: 4 LogP: 3.53 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC([C@H](c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C)C
InChi: 1S/C22H25N3O5/c1-11(2)16(15-10-9-12(3)30-15)24-18-17(20(27)21(18)28)23-14-8-6-7-13(19(14)26)22(29)25(4)5/h6-11,16,23-24,26H,1-5H3/t16-/m1/s1
InChiKey: QPGNAJBQDXRPEA-MRXNPFEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-2-methyl-1-(5-methyl-2-furyl)propyl]amino]-3,4-dioxo-cyclobuten-1-yl]amino]benzamide
2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-2-methyl-1-(5-methyl-2-furyl)propyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]benzamide
2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-2-methyl-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxo-cyclobuten-1-yl]amino]benzamide
3-[[3,4-diketo-2-[[(1R)-2-methyl-1-(5-methyl-2-furyl)propyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethyl-benzamide
2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-2-methyl-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]benzamide
3-[[3,4-diketo-2-[[(1R)-2-methyl-1-(5-methyl-2-furyl)propyl]amino]-1-cyclobutenyl]amino]-2-hydroxy-N,N-dimethyl-benzamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-X-C motif) receptor 2	Starlite/ChEMBL	References
Homo sapiens	chemokine (C-X-C motif) receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Echinococcus multilocularis	tissue type plasminogen activator	0.0479	0.1529	0.3257
Echinococcus multilocularis	enteropeptidase	0.035	0.0806	0.1718
Schistosoma mansoni	notch	0.0272	0.0372	0.016
Brugia malayi	Trypsin family protein	0.035	0.0806	0.0451
Schistosoma mansoni	hypothetical protein	0.0272	0.0372	0.016
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0637	0.2406	0.2113
Echinococcus granulosus	protein jagged 1	0.0272	0.0372	0.035
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.035	0.0806	0.0604
Schistosoma mansoni	hypothetical protein	0.0272	0.0372	0.016
Onchocerca volvulus		0.035	0.0806	0.0451
Brugia malayi	Trypsin family protein	0.035	0.0806	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0637	0.2406	0.2113
Brugia malayi	Calcium binding EGF domain containing protein	0.0637	0.2406	0.2113
Loa Loa (eye worm)	hypothetical protein	0.0704	0.278	0.2501
Echinococcus multilocularis	fibropellin Ia	0.0272	0.0372	0.0792
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.035	0.0806	0.0604
Echinococcus multilocularis	slit 2 protein	0.0272	0.0372	0.0792
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1999	1	1
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0637	0.2406	0.2239
Loa Loa (eye worm)	hypothetical protein	0.1999	1	1
Echinococcus multilocularis	neural cadherin	0.0272	0.0372	0.0792
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1999	1	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0272	0.0372	0.0792
Loa Loa (eye worm)	hypothetical protein	0.1999	1	1
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0637	0.2406	0.2113
Echinococcus multilocularis	Coagulation factor 5 8 type, C terminal	0.0244	0.0215	0.0458
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.035	0.0806	0.132
Loa Loa (eye worm)	TK/ROR protein kinase	0.0479	0.1529	0.1202
Echinococcus multilocularis	laminin	0.0637	0.2406	0.5125
Schistosoma mansoni	hypothetical protein	0.0272	0.0372	0.016
Echinococcus granulosus	neurogenic locus notch protein	0.0272	0.0372	0.035
Echinococcus multilocularis	fibrillin 1	0.0637	0.2406	0.5125
Echinococcus granulosus	neurogenic locus notch protein 4	0.0272	0.0372	0.035
Echinococcus granulosus	neurogenic locus protein delta	0.0272	0.0372	0.035
Echinococcus granulosus	glycoprotein Antigen 5	0.035	0.0806	0.132
Loa Loa (eye worm)	hypothetical protein	0.0643	0.2442	0.2151
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Echinococcus granulosus	enteropeptidase	0.035	0.0806	0.132
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0637	0.2406	0.7922
Brugia malayi	hypothetical protein	0.035	0.0806	0.0451
Toxoplasma gondii	PAN domain-containing protein	0.0732	0.294	1
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0637	0.2406	0.2113
Mycobacterium ulcerans	hypothetical protein	0.035	0.0806	0.5
Echinococcus granulosus	fibropellin Ia	0.0272	0.0372	0.035
Onchocerca volvulus		0.035	0.0806	0.0451
Onchocerca volvulus		0.035	0.0806	0.0451
Echinococcus granulosus	neurogenic locus notch protein	0.0272	0.0372	0.035
Brugia malayi	Kringle domain containing protein	0.0479	0.1529	0.1202
Schistosoma mansoni	cell polarity protein	0.0272	0.0372	0.016
Schistosoma mansoni	hypothetical protein	0.0272	0.0372	0.016
Echinococcus multilocularis	Tolloid protein 1	0.0637	0.2406	0.5125
Schistosoma mansoni	hypothetical protein	0.0272	0.0372	0.016
Loa Loa (eye worm)	hypothetical protein	0.035	0.0806	0.0451
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0637	0.2406	0.2113
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0637	0.2406	0.7922
Schistosoma mansoni	septate junction protein	0.031	0.0587	0.038
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.035	0.0806	0.0604
Echinococcus granulosus	protein jagged 2	0.0272	0.0372	0.035
Schistosoma mansoni	notch	0.0272	0.0372	0.016
Loa Loa (eye worm)	hypothetical protein	0.035	0.0806	0.0451
Schistosoma mansoni	slit	0.0272	0.0372	0.016
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Schistosoma mansoni	notch	0.0272	0.0372	0.016
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.035	0.0806	0.132
Brugia malayi	Trypsin family protein	0.035	0.0806	0.0451
Leishmania major	hypothetical protein, conserved	0.0479	0.1529	0.5
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.035	0.0806	0.0604
Echinococcus granulosus	tissue type plasminogen activator	0.0479	0.1529	0.2934
Loa Loa (eye worm)	hypothetical protein	0.035	0.0806	0.0451
Onchocerca volvulus		0.0479	0.1529	0.1202
Schistosoma mansoni	hypothetical protein	0.035	0.0806	0.0604
Echinococcus multilocularis	protein jagged 1	0.0272	0.0372	0.0792
Schistosoma mansoni	notch	0.0272	0.0372	0.016
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.035	0.0806	0.1718
Echinococcus multilocularis	neurogenic locus notch protein	0.0272	0.0372	0.0792
Onchocerca volvulus		0.035	0.0806	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0675	0.2621	0.2336
Echinococcus multilocularis	protein jagged 1	0.0272	0.0372	0.0792
Toxoplasma gondii	kringle domain-containing protein	0.0479	0.1529	0.4507
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.035	0.0806	0.0604
Brugia malayi	Protein kinase domain containing protein	0.0479	0.1529	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1529	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0637	0.2406	0.2113
Echinococcus granulosus	Mastin	0.035	0.0806	0.132
Onchocerca volvulus		0.035	0.0806	0.0451
Onchocerca volvulus		0.1649	0.805	0.7975
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Echinococcus multilocularis	neurogenic locus protein delta	0.0272	0.0372	0.0792
Schistosoma mansoni	hypothetical protein	0.0272	0.0372	0.016
Echinococcus multilocularis	glycoprotein Antigen 5	0.035	0.0806	0.1718
Echinococcus granulosus	neural cadherin	0.0272	0.0372	0.035
Loa Loa (eye worm)	hypothetical protein	0.0637	0.2406	0.2113
Onchocerca volvulus	Arrow homolog	0.0637	0.2406	0.2113
Schistosoma mansoni	notch	0.0272	0.0372	0.016
Loa Loa (eye worm)	hypothetical protein	0.035	0.0806	0.0451
Loa Loa (eye worm)	hypothetical protein	0.1213	0.5617	0.5448
Onchocerca volvulus		0.1999	1	1
Echinococcus granulosus	transmembrane protease serine 3	0.035	0.0806	0.132
Entamoeba histolytica	hypothetical protein	0.1092	0.4945	0.5
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0272	0.0372	0.016
Loa Loa (eye worm)	hypothetical protein	0.035	0.0806	0.0451
Trypanosoma cruzi	hypothetical protein, conserved	0.1092	0.4945	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0272	0.0372	0.0792
Brugia malayi	Trypsin-like protease protein 5	0.035	0.0806	0.0451
Echinococcus granulosus	tm gpcr rhodopsin	0.1047	0.4695	1
Schistosoma mansoni	laminin gamma-3 chain	0.0272	0.0372	0.016
Echinococcus granulosus	slit 2 protein	0.0272	0.0372	0.035
Loa Loa (eye worm)	hypothetical protein	0.0637	0.2406	0.2113
Schistosoma mansoni	hypothetical protein	0.0479	0.1529	0.1343
Echinococcus granulosus	protein jagged 1	0.0272	0.0372	0.035
Schistosoma mansoni	hypothetical protein	0.035	0.0806	0.0604
Echinococcus granulosus	laminin	0.0637	0.2406	0.4891
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0704	0.278	0.2501
Schistosoma mansoni	hypothetical protein	0.0272	0.0372	0.016
Echinococcus multilocularis	transmembrane protease serine 3	0.035	0.0806	0.1718
Brugia malayi	Fibulin-1 precursor	0.0637	0.2406	0.2113
Schistosoma mansoni	egf-like domain protein	0.0637	0.2406	0.2239
Trypanosoma cruzi	hypothetical protein, conserved	0.1092	0.4945	1
Echinococcus multilocularis	protein jagged 2	0.0272	0.0372	0.0792
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.035	0.0806	0.0451
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Plasmodium falciparum	cysteine repeat modular protein 1	0.0479	0.1529	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Echinococcus multilocularis	Mastin	0.035	0.0806	0.1718
Loa Loa (eye worm)	trypsin family protein	0.035	0.0806	0.0451
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0272	0.0372	0.0792
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0479	0.1529	0.5
Echinococcus granulosus	delta-like protein 1	0.0272	0.0372	0.035
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1047	0.4695	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.035	0.0806	0.0604
Echinococcus granulosus	Tolloid protein 1	0.0637	0.2406	0.4891
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.035	0.0806	0.1718
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0272	0.0372	0.0792
Echinococcus multilocularis	notch	0.0272	0.0372	0.0792
Echinococcus granulosus	protein jagged 2	0.0272	0.0372	0.035
Toxoplasma gondii	PAN domain-containing protein	0.0732	0.294	1
Giardia lamblia	High cysteine protein	0.0272	0.0372	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604
Echinococcus granulosus	notch	0.0272	0.0372	0.035
Schistosoma mansoni	notch	0.0272	0.0372	0.016
Schistosoma mansoni	cercarial elastase (S01 family)	0.035	0.0806	0.0604

Activities

Activity type	Activity value	Assay description	Source	Reference
AUC (ADMET)	= 3.2 uM.hr	AUC (0-6h) in rat at 10 mg/kg, po	ChEMBL.	17181143
IC50 (binding)	= 6.2 nM	Displacement of [125I]hCXCL8 from human CXCR2 receptor expressed in BaF3 cells	ChEMBL.	17181143
IC50 (binding)	= 6.2 nM	Displacement of [125I]hCXCL8 from human CXCR2 receptor expressed in BaF3 cells	ChEMBL.	17181143
IC50 (binding)	= 34 nM	Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cells	ChEMBL.	17181143
IC50 (binding)	= 34 nM	Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cells	ChEMBL.	17181143

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL384889
PubChem: 16098482

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 410325