Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | cystathionine beta-lyase, PLP-dependent | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Leishmania major | cysteine desulfhydrase | Get druggable targets OG5_136808 | All targets in OG5_136808 |
Leishmania braziliensis | cystathionine beta-lyase, putative | Get druggable targets OG5_136808 | All targets in OG5_136808 |
Leishmania infantum | cysteine desulfhydrase, putative | Get druggable targets OG5_136808 | All targets in OG5_136808 |
Leishmania donovani | cystathionine beta-lyase, putative | Get druggable targets OG5_136808 | All targets in OG5_136808 |
Leishmania mexicana | cystathionine beta-lyase, putative | Get druggable targets OG5_136808 | All targets in OG5_136808 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0267 | 0.0267 |
Echinococcus granulosus | twitchin | 0.0099 | 0.043 | 0.674 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0079 | 0.0267 | 0.4186 |
Echinococcus multilocularis | Immunoglobulin | 0.0079 | 0.0267 | 0.4186 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1288 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0125 | 0.0638 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0267 | 0.0267 |
Schistosoma mansoni | vesicular amine transporter | 0.0079 | 0.0267 | 0.5622 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0267 | 0.0267 |
Echinococcus granulosus | neuroglian | 0.0099 | 0.043 | 0.674 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0267 | 0.0267 |
Echinococcus granulosus | defective proboscis extension response | 0.0079 | 0.0267 | 0.4186 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0079 | 0.0267 | 0.5622 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0475 | 0.0475 |
Echinococcus multilocularis | Immunoglobulin | 0.0079 | 0.0267 | 0.4186 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0079 | 0.0267 | 0.0267 |
Echinococcus multilocularis | roundabout 2 | 0.0125 | 0.0638 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0105 | 0.0475 | 0.7446 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0638 | 0.0638 |
Schistosoma mansoni | nephrin | 0.0099 | 0.043 | 0.9052 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0267 | 0.0267 |
Leishmania major | cysteine desulfhydrase | 0.0362 | 0.2544 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0053 | 0.0058 | 0.122 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0079 | 0.0267 | 0.5622 |
Echinococcus multilocularis | neuroglian | 0.0099 | 0.043 | 0.674 |
Onchocerca volvulus | 0.1176 | 0.9096 | 0.9763 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0267 | 0.0267 |
Echinococcus granulosus | Immunoglobulin | 0.0079 | 0.0267 | 0.4186 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0079 | 0.0267 | 0.0267 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1203 | 0.9317 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0105 | 0.0475 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.9 uM | Inhibition of Escherichia coli CBL | ChEMBL. | 17300162 |
IC50 (binding) | = 5.9 uM | Inhibition of Escherichia coli CBL | ChEMBL. | 17300162 |
MIC (functional) | > 128 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 | ChEMBL. | 17300162 |
MIC (functional) | = 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 in presence of methionine | ChEMBL. | 17300162 |
MIC (functional) | = 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 in absence of methionine | ChEMBL. | 17300162 |
MIC (functional) | > 128 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 | ChEMBL. | 17300162 |
MIC (functional) | = 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 in presence of methionine | ChEMBL. | 17300162 |
MIC (functional) | = 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 in absence of methionine | ChEMBL. | 17300162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.