Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1446 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1446 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0428 | 0.284 | 0.284 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1446 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1446 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1446 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 74 % | Agonist potency at PPARdelta in CV1 cells relative to GW501516 | ChEMBL. | 17243659 |
Activity (functional) | = 74 % | Agonist potency at PPARdelta in CV1 cells relative to GW501516 | ChEMBL. | 17243659 |
Activity (functional) | = 82 % | Agonist potency at PPARalpha expressed in CV1 cells relative to GW590735 | ChEMBL. | 17243659 |
Activity (functional) | = 82 % | Agonist potency at PPARalpha expressed in CV1 cells relative to GW590735 | ChEMBL. | 17243659 |
EC50 (functional) | = 0.465 uM | Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay | ChEMBL. | 17243659 |
EC50 (functional) | = 0.465 uM | Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay | ChEMBL. | 17243659 |
EC50 (functional) | = 0.808 uM | Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay | ChEMBL. | 17243659 |
EC50 (functional) | = 0.808 uM | Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay | ChEMBL. | 17243659 |
EC50 (functional) | > 25 uM | Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay | ChEMBL. | 17243659 |
EC50 (functional) | > 25 uM | Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay | ChEMBL. | 17243659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.