Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0135 | 0.0947 | 0.4778 |
Entamoeba histolytica | kinesin, putative | 0.0135 | 0.0947 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0238 | 0.1981 | 0.1981 |
Loa Loa (eye worm) | serotonin transporter b | 0.0238 | 0.1981 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0238 | 0.1981 | 0.2291 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0238 | 0.1981 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0238 | 0.1981 | 0.1981 |
Schistosoma mansoni | hypothetical protein | 0.0903 | 0.8648 | 1 |
Plasmodium vivax | kinesin-5 | 0.0135 | 0.0947 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1981 | 1 |
Onchocerca volvulus | 0.0238 | 0.1981 | 1 | |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.004 | 0 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0135 | 0.0947 | 0.4778 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0135 | 0.0947 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.1037 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0238 | 0.1981 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0135 | 0.0947 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0238 | 0.1981 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0238 | 0.1981 | 0.2291 |
Schistosoma mansoni | kinesin eg-5 | 0.0135 | 0.0947 | 0.1095 |
Giardia lamblia | Kinesin-5 | 0.0135 | 0.0947 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1981 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0238 | 0.1981 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.04 uM | Inhibition of human eosinophil phosphodiesterase | ChEMBL. | 17228876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.