Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0338 | 0.6377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.2777 | 0.2746 |
Brugia malayi | Protein kinase c protein 2 | 0.0259 | 0.4418 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0081 | 0.0043 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0213 | 0.3296 | 0.5135 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Toxoplasma gondii | AGC kinase | 0.0081 | 0.0043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.7997 | 0.7988 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0192 | 0.2777 | 0.4316 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0338 | 0.6377 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0081 | 0.0043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.9413 | 0.9411 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0192 | 0.2777 | 0.4316 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0281 | 0.4961 | 0.7764 |
Entamoeba histolytica | protein kinase, putative | 0.0081 | 0.0043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.7997 | 0.7988 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0338 | 0.6377 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0081 | 0.0043 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0192 | 0.2777 | 0.4316 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.4193 | 0.4168 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.7997 | 0.7988 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0213 | 0.3296 | 0.3267 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0338 | 0.6377 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0281 | 0.4961 | 0.7764 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0139 | 0.1459 | 0.2236 |
Echinococcus multilocularis | protein kinase c iota type | 0.0139 | 0.1459 | 0.2236 |
Brugia malayi | protein kinase C II. | 0.0213 | 0.3296 | 0.7436 |
Onchocerca volvulus | 0.0404 | 0.7997 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0213 | 0.3296 | 0.5135 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0148 | 0.1699 | 0.2614 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0213 | 0.3296 | 0.5135 |
Echinococcus granulosus | protein kinase c iota type | 0.0139 | 0.1459 | 0.2236 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0201 | 0.3001 | 0.2971 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0043 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0081 | 0.0043 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP (functional) | NA 0 mmHg | Antihypertensive activity in spontaneously hypertensive rats, measured as average blood pressure at 100 mg/kg,po before predose; No significant lowering of blood pressure | ChEMBL. | 7452694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.