Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 8 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0849 | 0.6744 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0849 | 0.6744 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1053 | 0.8771 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0849 | 0.6744 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1053 | 0.8771 | 0.8654 |
Onchocerca volvulus | 0.026 | 0.0875 | 0.2476 | |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1176 | 1 | 1 |
Onchocerca volvulus | 0.042 | 0.2472 | 1 | |
Echinococcus granulosus | dihydrofolate reductase | 0.1053 | 0.8771 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1176 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1053 | 0.8771 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1053 | 0.8771 | 0.5 |
Brugia malayi | thymidylate synthase | 0.042 | 0.2472 | 0.2582 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1053 | 0.8771 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1053 | 0.8771 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.042 | 0.2472 | 0.2818 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.028 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1053 | 0.8771 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0849 | 0.6744 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1053 | 0.8771 | 0.8654 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0849 | 0.6744 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0849 | 0.6744 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.026 | 0.0875 | 0.0998 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.042 | 0.2472 | 0.175 |
Mycobacterium ulcerans | thymidylate synthase | 0.042 | 0.2472 | 0.175 |
Brugia malayi | dihydrofolate reductase family protein | 0.1053 | 0.8771 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.02 | 0.028 | 0.0319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 612.5 nM | Antagonist activity against human CCR8 expressed in CHO/Galpha16 cells assessed as inhibition of CCL1-induced increase of intracellular calcium by FLIPR assay | ChEMBL. | 17266208 |
IC50 (functional) | = 612.5 nM | Antagonist activity against human CCR8 expressed in CHO/Galpha16 cells assessed as inhibition of CCL1-induced increase of intracellular calcium by FLIPR assay | ChEMBL. | 17266208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.