Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0027 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0027 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0027 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.4775 | 0.4775 |
Giardia lamblia | DINP protein human, muc B family | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.4775 | 0.4775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0027 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0027 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0012 | 0 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0019 | 0.4775 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 74.14 % | Inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cells at 10 uM relative to control | ChEMBL. | 16950619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.