Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glutathione reductase, putative | 0.0094 | 0.1026 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.7978 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0069 | 0.0144 | 0.0181 |
Loa Loa (eye worm) | glutathione reductase | 0.0272 | 0.7289 | 0.9136 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0069 | 0.0144 | 0.0181 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0171 | 0.3722 | 0.3879 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0094 | 0.1026 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.7978 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0272 | 0.7289 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.7978 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0297 | 0.8147 | 1 |
Leishmania major | trypanothione reductase | 0.0272 | 0.7289 | 1 |
Onchocerca volvulus | 0.0292 | 0.7978 | 1 | |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0272 | 0.7289 | 0.8795 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0272 | 0.7289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.4165 | 0.522 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.7978 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0094 | 0.1026 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.7978 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0272 | 0.7289 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0094 | 0.1026 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0171 | 0.3722 | 0.3879 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.7978 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.7978 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0272 | 0.7289 | 0.9009 |
Trypanosoma brucei | trypanothione reductase | 0.0272 | 0.7289 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0094 | 0.1026 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0272 | 0.7289 | 0.9136 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3722 | 0.4666 |
Plasmodium falciparum | glutathione reductase | 0.0272 | 0.7289 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0272 | 0.7289 | 0.9009 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.7978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.7978 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0184 | 0.4165 | 0.522 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.7978 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0349 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0272 | 0.7289 | 0.9136 |
Brugia malayi | glutathione reductase | 0.0272 | 0.7289 | 0.9136 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0094 | 0.1026 | 0.1286 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3722 | 0.4666 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0171 | 0.3722 | 0.3879 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0094 | 0.1026 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0272 | 0.7289 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.7978 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0272 | 0.7289 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.7978 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0094 | 0.1026 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.1 nM | Binding affinity to CCR3 | ChEMBL. | 16931001 |
Ki (binding) | = 217 nM | Inhibition of 5HTT | ChEMBL. | 16931001 |
Ki (binding) | = 217 nM | Inhibition of 5HTT | ChEMBL. | 16931001 |
Ki (binding) | = 855 nM | Inhibition of DAT | ChEMBL. | 16931001 |
Ki (binding) | = 855 nM | Inhibition of DAT | ChEMBL. | 16931001 |
Ki (binding) | = 1230 nM | Inhibition of NET | ChEMBL. | 16931001 |
Ki (binding) | = 1230 nM | Inhibition of NET | ChEMBL. | 16931001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.