Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 10 | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0131 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0694 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0694 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.024 | 0.1924 | 0.0448 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0417 | 0.5074 | 0.4174 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0417 | 0.5074 | 0.4174 |
Trypanosoma brucei | prolyl endopeptidase | 0.0218 | 0.1546 | 0.2717 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0694 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0451 | 0.5689 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0329 | 0.3507 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0451 | 0.5689 | 0.4901 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0451 | 0.5689 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0557 | 0.7559 | 0.7152 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0451 | 0.5689 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0451 | 0.5689 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0218 | 0.1546 | 0.2717 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0557 | 0.7559 | 0.7113 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0694 | 1 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0557 | 0.7559 | 0.7113 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0694 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.0131 | 0 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0451 | 0.5689 | 0.4901 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0451 | 0.5689 | 0.4901 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0131 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1924 | 0.0576 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0557 | 0.7559 | 0.7113 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0451 | 0.5689 | 0.4901 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1546 | 0.0134 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0218 | 0.1546 | 0.2717 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0557 | 0.7559 | 0.7113 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0451 | 0.5689 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0417 | 0.5074 | 0.4174 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0131 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.699 | Inhibition of JNK1 | ChEMBL. | 17602798 |
IC50 (functional) | = 0.2 uM | Inhibition of JNK1 by ATF2 phosphorylation assay | ChEMBL. | 16971120 |
IC50 (functional) | = 0.2 uM | Inhibition of JNK1 by ATF2 phosphorylation assay | ChEMBL. | 16971120 |
IC50 (functional) | = 0.24 uM | Inhibition of JNK2 by ATF2 phosphorylation assay | ChEMBL. | 16971120 |
IC50 (functional) | = 0.24 uM | Inhibition of JNK2 by ATF2 phosphorylation assay | ChEMBL. | 16971120 |
IC50 (functional) | = 9.4 uM | Inhibition of PcJun phosphorylation in HepG2 cells | ChEMBL. | 16971120 |
IC50 (functional) | = 9.4 uM | Inhibition of PcJun phosphorylation in HepG2 cells | ChEMBL. | 16971120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.