Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | adenosine kinase, putative | 0.026 | 0.1351 | 0.5 |
Echinococcus multilocularis | sodium:nucleoside cotransporter 2 | 0.0558 | 0.568 | 0.568 |
Echinococcus multilocularis | adenosine kinase | 0.026 | 0.1351 | 0.1351 |
Trypanosoma cruzi | adenosine kinase, putative | 0.026 | 0.1351 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.026 | 0.1351 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.026 | 0.1351 | 0.5 |
Echinococcus multilocularis | solute carrier family 28 | 0.0855 | 1 | 1 |
Echinococcus granulosus | Na+ dependent nucleoside transporter | 0.0855 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.1351 | 1 |
Echinococcus multilocularis | concentrative Na+ nucleoside cotransporter | 0.0855 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.026 | 0.1351 | 0.5 |
Echinococcus granulosus | concentrative Na nucleoside cotransporter | 0.0855 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.026 | 0.1351 | 1 |
Brugia malayi | Adenosine kinase-like | 0.026 | 0.1351 | 1 |
Echinococcus granulosus | adenosine kinase | 0.026 | 0.1351 | 0.1351 |
Trypanosoma cruzi | adenosine kinase, putative | 0.026 | 0.1351 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.026 | 0.1351 | 0.5 |
Onchocerca volvulus | 0.023 | 0.0921 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 83 uM | In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor | ChEMBL. | 10360746 |
IC50 (binding) | = 83 uM | In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor | ChEMBL. | 10360746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.