Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.037 | 0.1156 | 1 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.2342 | 1 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0049 | 0.1592 |
Leishmania major | C-8 sterol isomerase-like protein | 0.037 | 0.1156 | 0.0909 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.0272 | 1 |
Schistosoma mansoni | integrin alpha | 0.0148 | 0.0162 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2342 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.2342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1156 | 0.1156 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0148 | 0.0162 | 0.0162 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.2342 | 1 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.037 | 0.1156 | 0.1156 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.2342 | 1 | 1 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.0272 | 0.0272 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0049 | 0.1592 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2342 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.037 | 0.1156 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0049 | 0.1592 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.2342 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0999 | 0.3978 | 0.3978 |
Onchocerca volvulus | 0.0173 | 0.0272 | 0.5 | |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.0272 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0229 | 0.0522 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0019 | 0.0019 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.2342 | 1 | 0.5 |
Brugia malayi | amidase | 0.0123 | 0.0049 | 0.0049 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0049 | 0.1592 |
Brugia malayi | Lipase family protein | 0.0173 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0999 | 0.3978 | 0.3978 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0049 | 0.0049 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0345 | 0.0345 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.2342 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 | Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay | ChEMBL. | 26584396 |
Ki (binding) | = 0.1 uM | Inhibition of rat recombinant FAAH expressed in E.coli by [14C]oleamide breakdown | ChEMBL. | 17279740 |
Ki (binding) | = 0.1 uM | Inhibition of rat recombinant FAAH expressed in E.coli by [14C]oleamide breakdown | ChEMBL. | 17279740 |
Ki (binding) | = 0.1 uM | Inhibition of FAAH | ChEMBL. | 18983142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.