Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | AKH receptor | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | G protein-coupled receptor | 0.0036 | 0.0917 | 0.0917 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 1 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | RE15519p | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | G-protein coupled receptor | 0.0036 | 0.0917 | 0.0917 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.6692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Brugia malayi | putative neuropeptide receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.6692 | 0.6358 |
Brugia malayi | larval opioid receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | lipase | 0.0173 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 1 | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Melatonin receptor type 1A | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | GnHR receptor homolog | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | neuropeptide F receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.0173 | 1 | 1 | |
Brugia malayi | amidase | 0.0123 | 0.6692 | 0.6692 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.6692 | 0.6358 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Serotonin receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.6692 | 0.6358 |
Brugia malayi | follicle stimulating hormone receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.068 | 0.068 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | sulfakinin receptor protein | 0.0036 | 0.0917 | 0.0917 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.6692 | 0.6358 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0036 | 0.0917 | 0.0917 |
Schistosoma mansoni | amidase | 0.0123 | 0.6692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Dopamine receptor | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | ORL1-like opioid receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | G-protein coupled receptor | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.068 | 0.068 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.6692 | 0.6692 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 1 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | neuropeptide F receptor | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | Dopamine receptor protein 2 | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0917 | 0.0917 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 | Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay | ChEMBL. | 26584396 |
Ki (binding) | = 0.065 uM | Inhibition of rat recombinant FAAH expressed in E.coli by [14C]oleamide breakdown | ChEMBL. | 17279740 |
Ki (binding) | = 0.065 uM | Inhibition of rat recombinant FAAH expressed in E.coli by [14C]oleamide breakdown | ChEMBL. | 17279740 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.