Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | prolyl endopeptidase | 0.0187 | 0.0756 | 0.1999 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0063 | 0.0831 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0855 | 0.3781 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0074 | 0.0074 |
Plasmodium vivax | hypothetical protein, conserved | 0.0187 | 0.0756 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2228 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0187 | 0.0756 | 0.0756 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0855 | 0.3781 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0187 | 0.0756 | 0.216 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0187 | 0.0756 | 0.216 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0187 | 0.0756 | 0.0756 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0187 | 0.0756 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0089 | 0.0089 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0187 | 0.0756 | 0.1999 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0187 | 0.0756 | 0.0756 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0187 | 0.0756 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0187 | 0.0756 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0855 | 0.3781 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0063 | 0.0831 |
Trypanosoma cruzi | oligopeptidase b | 0.0187 | 0.0756 | 0.1999 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0187 | 0.0756 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0605 | 0.2652 | 0.2652 |
Trypanosoma cruzi | oligopeptidase b | 0.0187 | 0.0756 | 0.1999 |
Echinococcus granulosus | prolyl endopeptidase | 0.0187 | 0.0756 | 0.0756 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0855 | 0.3781 | 0.3781 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0187 | 0.0756 | 0.0756 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2228 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0187 | 0.0756 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0187 | 0.0756 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0855 | 0.3781 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.037 | 0.1587 | 0.1587 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0187 | 0.0756 | 0.1999 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0187 | 0.0756 | 0.0756 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0855 | 0.3781 | 0.3781 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0187 | 0.0756 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0074 | 0.0074 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0187 | 0.0756 | 0.0756 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0792 | 0.3498 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0187 | 0.0756 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0187 | 0.0756 | 0.0756 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.037 | 0.1587 | 0.1587 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1038 | 0.1038 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0756 | 0.0756 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.037 | 0.1587 | 0.1587 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0187 | 0.0756 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0187 | 0.0756 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0855 | 0.3781 | 0.3781 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0187 | 0.0756 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0074 | 0.0074 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0089 | 0.0089 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0187 | 0.0756 | 0.0756 |
Toxoplasma gondii | hypothetical protein | 0.0187 | 0.0756 | 0.216 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0855 | 0.3781 | 0.3781 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0187 | 0.0756 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0187 | 0.0756 | 0.1999 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0756 | 0.0756 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0187 | 0.0756 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0855 | 0.3781 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2228 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2228 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0187 | 0.0756 | 0.0756 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0187 | 0.0756 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0187 | 0.0756 | 0.0756 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0074 | 0.0074 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0187 | 0.0756 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0187 | 0.0756 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2228 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0605 | 0.2652 | 0.2652 |
Mycobacterium tuberculosis | Probable peptidase | 0.0187 | 0.0756 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0187 | 0.0756 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0187 | 0.0756 | 0.1999 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.14 mol/L | DPPH radical scavenging activity | ChEMBL. | 16950623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.