Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum FcB1/Columbia | Zinc aminopeptidase | Starlite/ChEMBL | References |
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aminopeptidase N protein | 0.039 | 1 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0158 | 0.3254 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0158 | 0.3254 | 1 |
Toxoplasma gondii | aminopeptidase N, putative | 0.039 | 1 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0321 | 0.0986 |
Loa Loa (eye worm) | aminopeptidase N | 0.0057 | 0.0321 | 0.1304 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0131 | 0.2461 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0089 | 0.1262 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.16 | 0.6503 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0057 | 0.0321 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0057 | 0.0321 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Echinococcus granulosus | aminopeptidase N | 0.0158 | 0.3254 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0057 | 0.0321 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Toxoplasma gondii | aminopeptidase n, putative | 0.039 | 1 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0057 | 0.0321 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0057 | 0.0321 | 0.5 |
Onchocerca volvulus | 0.0057 | 0.0321 | 0.0986 | |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.039 | 1 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0057 | 0.0321 | 0.2544 |
Brugia malayi | Peptidase family M1 containing protein | 0.0057 | 0.0321 | 0.0986 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0057 | 0.0321 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0057 | 0.0321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.2394 | 0.9728 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0057 | 0.0321 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0057 | 0.0321 | 0.0986 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0057 | 0.0321 | 0.2544 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Onchocerca volvulus | 0.0158 | 0.3254 | 1 | |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0057 | 0.0321 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0057 | 0.0321 | 0.0986 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.1262 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 225 nM | Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase | ChEMBL. | 17326615 |
IC50 (binding) | = 225 nM | Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase | ChEMBL. | 17326615 |
IC50 (binding) | > 10000 nM | Inhibition of microsomal neural aminopeptidase in pig kidney | ChEMBL. | 17070058 |
IC50 (binding) | > 10000 nM | Inhibition of microsomal neural aminopeptidase in pig kidney | ChEMBL. | 17070058 |
Inhibition (binding) | = 84 % | Inhibition of pig kidney microsomal APN at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 84 % | Inhibition of pig kidney microsomal APN at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 96 % | Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 96 % | Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM | ChEMBL. | 17326615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.