Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Gallus gallus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0143 | 0.0364 | 0.0171 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0883 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0116 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1514 | 0.1343 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.05 | 0.5016 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0883 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5016 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0231 | 0.1514 | 0.0889 |
Echinococcus granulosus | dihydrofolate reductase | 0.0883 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0231 | 0.1514 | 0.1343 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0231 | 0.1514 | 0.1343 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0143 | 0.0364 | 0.0364 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0883 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0231 | 0.1514 | 0.0889 |
Echinococcus granulosus | methionine synthase reductase | 0.0143 | 0.0364 | 0.0171 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0231 | 0.1514 | 0.1343 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0231 | 0.1514 | 0.1343 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0231 | 0.1514 | 0.1514 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0231 | 0.1514 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5016 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0883 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.0197 | 0.0197 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0883 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0231 | 0.1514 | 0.1343 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0231 | 0.1514 | 0.1343 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0205 | 0.1172 | 0.5 |
Onchocerca volvulus | 0.013 | 0.0197 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0883 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0883 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5016 | 1 |
Giardia lamblia | Hypothetical protein | 0.0205 | 0.1172 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5016 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0231 | 0.1514 | 0.1343 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0231 | 0.1514 | 0.0889 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0883 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0231 | 0.1514 | 0.1343 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5016 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0143 | 0.0364 | 0.0171 |
Brugia malayi | FAD binding domain containing protein | 0.0143 | 0.0364 | 0.0171 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.75 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
Ki (binding) | = 5.99 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Ki (binding) | = 7.12 | Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Ki app (binding) | = 4.96 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR) | ChEMBL. | 6796688 |
Ki app (binding) | = 4.96 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR) | ChEMBL. | 6796688 |
Log 1/C (binding) | = 6.39 | Inhibitory activity against dihydrofolate reductase isolated from murine L5178Y tumor cells resistant to methotrexate. | ChEMBL. | 6699880 |
Log 1/C (binding) | = 7.97 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (functional) | = 5.02 | Inhibitory activity against methotrexate- resistant Lactobacillus casei cells | ChEMBL. | 6796688 |
Log 1/C (functional) | = 6.39 | Compound was tested in vitro for concentration required to decrease 50% growth rate of murine leukemia L5178Y/R cell culture | ChEMBL. | 7057421 |
Log 1/C (binding) | = 6.39 | Inhibitory activity against dihydrofolate reductase isolated from murine L5178Y tumor cells resistant to methotrexate. | ChEMBL. | 6699880 |
Log 1/C (functional) | = 6.45 | Inhibitory activity against methotrexate- sensitive Lactobacillus casei cells | ChEMBL. | 6796688 |
Log 1/C (binding) | = 7.97 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/Ki (binding) | = 5.99 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Log 1/Ki (binding) | = 7.12 | Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Log 1/Ki app (binding) | = 5.75 | Inhibition of Escherichia coli dihydrofolate reductase. | ChEMBL. | 3934385 |
Log Ki (binding) | = 5.75 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
6 literature references were collected for this gene.