Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0232 | 0.0356 | 0.0348 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.339 | 1 | 0.5 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0139 | 0.0072 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0383 | 0.0819 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0383 | 0.0819 | 0.0753 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.339 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.339 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0139 | 0.0072 | 1 |
Onchocerca volvulus | 0.0139 | 0.0072 | 0.5 | |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.339 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0383 | 0.0819 | 0.5 |
Echinococcus granulosus | sodium channel nonvoltage gated 1 alpha | 0.0139 | 0.0072 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.339 | 1 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.339 | 1 | 1 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0139 | 0.0072 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.0819 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.339 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | protein vprbp | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1446 | 0.4064 | 0.4059 |
Echinococcus granulosus | amiloride sensitive cation channel | 0.0139 | 0.0072 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel | 0.0139 | 0.0072 | 0.0063 |
Schistosoma mansoni | integrin alpha | 0.015 | 0.0107 | 1 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0139 | 0.0072 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.339 | 1 | 0.5 |
Echinococcus multilocularis | amiloride sensitive cation channel acid sensing ion channel pituitary | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0246 | 0.0238 |
Echinococcus multilocularis | sodium channel nonvoltage gated 1 alpha | 0.0139 | 0.0072 | 1 |
Echinococcus multilocularis | protein vprbp | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | degenerin unc-8 | 0.0139 | 0.0072 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus granulosus | amiloride sensitive sodium channel | 0.0139 | 0.0072 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1446 | 0.4064 | 0.4059 |
Onchocerca volvulus | 0.0139 | 0.0072 | 0.5 | |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.339 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.339 | 1 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0139 | 0.0072 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.015 | 0.0107 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | < 1 ug ml-1 | Cytotoxicity against human HT29 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | < 1 ug ml-1 | Cytotoxicity against human HT29 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 6 ug ml-1 | Cytotoxicity against human L132 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 6 ug ml-1 | Cytotoxicity against human PA1 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 6 ug ml-1 | Cytotoxicity against human L132 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 18.5 ug ml-1 | Cytotoxicity against human MiaPaCa2 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 18.5 ug ml-1 | Cytotoxicity against human MiaPaCa2 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 35 ug ml-1 | Cytotoxicity against human KB cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 35 ug ml-1 | Cytotoxicity against human KB cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 92 ug ml-1 | Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 92 ug ml-1 | Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human DU145 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human DU145 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17373779 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.