Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Brugia malayi | Degenerin mec-4 | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | sodium channel nonvoltage gated 1 alpha | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | amiloride sensitive cation channel acid sensing ion channel pituitary | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | protein vprbp | 0.0154 | 0.5 | 0.5 |
Brugia malayi | amiloride-sensitive sodium channel alpha-subunit, putative | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0154 | 0.5 | 0.5 |
Brugia malayi | Degenerin-like protein C41C4.5 in chromosome II, putative | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0154 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0154 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0154 | 0.5 | 0.5 | |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | FMRFamide-gated Na+ channel | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | protein vprbp | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | degenerin unc-8 | 0.0154 | 0.5 | 0.5 |
Brugia malayi | Amiloride-sensitive sodium channel family protein | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | sodium channel nonvoltage gated 1 alpha | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | acid sensing ion channel 4 pituitary | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | amiloride sensitive cation channel | 0.0154 | 0.5 | 0.5 |
Brugia malayi | Degenerin unc-8 | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0154 | 0.5 | 0.5 |
Brugia malayi | Amiloride-sensitive sodium channel family protein | 0.0154 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0154 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.5 | 0.5 |
Echinococcus granulosus | amiloride sensitive sodium channel | 0.0154 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 50 % | Displacement of [3H]N-methyl-scopalamine from human muscarinic M3 receptor expressed in CHO K1 cells at 10 uM | ChEMBL. | 17352462 |
Inhibition (binding) | < 50 % | Displacement of [3H]N-methyl-scopalamine from human muscarinic M3 receptor expressed in CHO K1 cells at 10 uM | ChEMBL. | 17352462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.