Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.015 | 0.0107 | 0.0036 |
Trichomonas vaginalis | conserved hypothetical protein | 0.339 | 1 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0139 | 0.0072 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.339 | 1 | 1 |
Onchocerca volvulus | 0.0139 | 0.0072 | 0.5 | |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1446 | 0.4064 | 0.4059 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus granulosus | amiloride sensitive sodium channel | 0.0139 | 0.0072 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | degenerin unc-8 | 0.0139 | 0.0072 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Echinococcus multilocularis | sodium channel nonvoltage gated 1 alpha | 0.0139 | 0.0072 | 1 |
Echinococcus multilocularis | protein vprbp | 0.0139 | 0.0072 | 1 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.339 | 1 | 0.5 |
Echinococcus multilocularis | amiloride sensitive cation channel acid sensing ion channel pituitary | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0246 | 0.0238 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Schistosoma mansoni | integrin alpha | 0.015 | 0.0107 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel | 0.0139 | 0.0072 | 0.0063 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | amiloride sensitive cation channel | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1446 | 0.4064 | 0.4059 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | protein vprbp | 0.0139 | 0.0072 | 1 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.0819 | 0.0811 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.339 | 1 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0139 | 0.0072 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.339 | 1 | 1 |
Echinococcus granulosus | sodium channel nonvoltage gated 1 alpha | 0.0139 | 0.0072 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.339 | 1 | 0.5 |
Onchocerca volvulus | 0.0139 | 0.0072 | 0.5 | |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.339 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0383 | 0.0819 | 0.5 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.339 | 1 | 0.5 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.339 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0139 | 0.0072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0383 | 0.0819 | 0.0753 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0383 | 0.0819 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0072 | 0.0063 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0139 | 0.0072 | 0.0063 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0232 | 0.0356 | 0.0348 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0139 | 0.0072 | 1 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.339 | 1 | 0.5 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0139 | 0.0072 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | 0 | Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | < 1 ug ml-1 | Cytotoxicity against human HT29 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | < 1 ug ml-1 | Cytotoxicity against human MiaPaCa2 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | < 1 ug ml-1 | Cytotoxicity against human PA1 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | < 1 ug ml-1 | Cytotoxicity against human HT29 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | < 1 ug ml-1 | Cytotoxicity against human MiaPaCa2 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 18 ug ml-1 | Cytotoxicity against human Hep2 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 18 ug ml-1 | Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 72 ug ml-1 | Cytotoxicity against human KB cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | = 72 ug ml-1 | Cytotoxicity against human KB cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human DU145 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human L132 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human DU145 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
IC50 (ADMET) | > 100 ug ml-1 | Cytotoxicity against human L132 cells after 72 hrs by MTT assay | ChEMBL. | 17373779 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17373779 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.