Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0148 | 0.1828 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0148 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0148 | 0.1828 | 0.1323 |
Echinococcus multilocularis | cathepsin b | 0.0441 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0103 | 0.0582 | 0.0582 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0162 | 0.2232 | 0.2232 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0441 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0441 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0441 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0441 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1828 | 0.1323 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin b | 0.0441 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0441 | 1 | 1 |
Toxoplasma gondii | cathepsin B | 0.0162 | 0.2232 | 1 |
Onchocerca volvulus | 0.0148 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0441 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0103 | 0.0582 | 0.2606 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0103 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0148 | 0.1828 | 0.1323 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0148 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0148 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Onchocerca volvulus | Cathepsin L homolog | 0.0148 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0148 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0162 | 0.2232 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0148 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin l1 | 0.0148 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0103 | 0.0582 | 0.0582 |
Brugia malayi | Cathepsin L-like precursor | 0.0148 | 0.1828 | 0.1828 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0148 | 0.1828 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0103 | 0.0582 | 0.0582 |
Onchocerca volvulus | 0.0148 | 0.1828 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0162 | 0.2232 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0148 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0148 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0103 | 0.0582 | 0.2606 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0148 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0148 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0162 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine protease, putative | 0.0148 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0148 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0148 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0148 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0103 | 0.0582 | 0.0582 |
Plasmodium vivax | vivapain-2 | 0.0148 | 0.1828 | 1 |
Onchocerca volvulus | 0.0148 | 0.1828 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0148 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0148 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0148 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0148 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0162 | 0.2232 | 0.2232 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0148 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Onchocerca volvulus | Cathepsin F homolog | 0.0148 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0148 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0148 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0148 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0103 | 0.0582 | 0.0582 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0148 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | ctsf protein | 0.0148 | 0.1828 | 0.1323 |
Onchocerca volvulus | 0.0148 | 0.1828 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0148 | 0.1828 | 0.1323 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0148 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0148 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0148 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | cathepsin B | 0.0162 | 0.2232 | 0.1752 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin b | 0.0441 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0103 | 0.0582 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0148 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0148 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0162 | 0.2232 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0148 | 0.1828 | 0.1323 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0148 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0148 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0162 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0148 | 0.1828 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0148 | 0.1828 | 0.1828 |
Brugia malayi | cathepsin L-like precursor | 0.0103 | 0.0582 | 0.0582 |
Giardia lamblia | Cathepsin B precursor | 0.0162 | 0.2232 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.1828 | 0.8189 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/Km (ADMET) | = 4.01 | Michaelis constant for Actinidin-catalyzed hydrolysis | ChEMBL. | 6387119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.