TDR Targets

Basic information

Technical information

TDR Targets ID: 417345
Name: 4-[4-(6-morpholin-4-yl-4-oxothiopyran-2-yl)ph enyl]benzonitrile
MW: 374.456 | Formula: C22H18N2O2S
H donors: 0 H acceptors: 2 LogP: 3.61 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc(cc1)c1ccc(cc1)c1cc(=O)cc(s1)N1CCOCC1
InChi: 1S/C22H18N2O2S/c23-15-16-1-3-17(4-2-16)18-5-7-19(8-6-18)21-13-20(25)14-22(27-21)24-9-11-26-12-10-24/h1-8,13-14H,9-12H2
InChiKey: ANLCVQLXDPDBJI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[4-(6-morpholino-4-oxo-thiopyran-2-yl)phenyl]benzonitrile
4-[4-(6-morpholino-4-oxo-2-thiopyranyl)phenyl]benzonitrile
4-[4-(6-morpholin-4-yl-4-oxo-thiopyran-2-yl)phenyl]benzenecarbonitrile
4-[4-(4-keto-6-morpholino-thiopyran-2-yl)phenyl]benzonitrile
4-[4-(6-morpholin-4-yl-4-oxo-thiopyran-2-yl)phenyl]benzonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g-protein coupled receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.006	0.1119	0.1119
Echinococcus multilocularis	g protein coupled receptor	0.006	0.1119	0.1119
Schistosoma mansoni	amine GPCR	0.006	0.1119	0.1119
Echinococcus granulosus	allatostatin A receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	TYRA-2 protein	0.006	0.1119	0.1119
Brugia malayi	putative neuropeptide receptor NPR1	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.006	0.1119	0.1119
Echinococcus granulosus	biogenic amine 5HT receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.006	0.1119	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Brugia malayi	AKH receptor	0.006	0.1119	0.1119
Echinococcus granulosus	neuropeptide Y receptor	0.006	0.1119	0.1119
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0138	0.3426	1
Schistosoma mansoni	biogenic amine receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Echinococcus granulosus	sex peptide receptor	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Echinococcus granulosus	fmrfamide receptor	0.006	0.1119	0.1119
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0361	1	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Echinococcus multilocularis	neuropeptide receptor	0.006	0.1119	0.1119
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	G protein coupled receptor 139	0.006	0.1119	0.1119
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.006	0.1119	0.1119
Onchocerca volvulus	Neuropeptide F receptor homolog	0.006	0.1119	0.5
Echinococcus granulosus	serotonin receptor	0.006	0.1119	0.1119
Echinococcus granulosus	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	neuropeptide s receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.006	0.1119	0.1119
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.006	0.1119	0.1119
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.006	0.1119	0.1119
Giardia lamblia	GTOR	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Brugia malayi	Serotonin receptor	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.006	0.1119	0.1119
Loa Loa (eye worm)	G-protein coupled receptor	0.006	0.1119	0.1119
Brugia malayi	GnHR receptor homolog	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus multilocularis	sex peptide receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Schistosoma mansoni	hypothetical protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	dihydrofolate reductase	0.0361	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	G protein coupled receptor 139	0.006	0.1119	0.1119
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0138	0.3426	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.006	0.1119	0.1119
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	amine GPCR	0.006	0.1119	0.1119
Echinococcus multilocularis	dihydrofolate reductase	0.0361	1	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	opsin-like receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	G-protein coupled receptor	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Brugia malayi	sulfakinin receptor protein	0.006	0.1119	0.1119
Schistosoma mansoni	myosin xvIII	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	neuropeptide F receptor	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	Dopamine receptor	0.006	0.1119	0.1119
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.006	0.1119	0.1119
Brugia malayi	Serotonin receptor	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.006	0.1119	0.1119
Schistosoma mansoni	neuropeptide receptor	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0138	0.3426	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.006	0.1119	0.1119
Brugia malayi	Dihydrofolate reductase	0.0361	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.006	0.1119	0.1119
Echinococcus granulosus	tachykinin peptides receptor 99D	0.006	0.1119	0.1119
Loa Loa (eye worm)	melatonin receptor type 1A	0.006	0.1119	0.1119
Schistosoma mansoni	amine GPCR	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	alpha-1 adrenergic receptor	0.006	0.1119	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Echinococcus granulosus	g protein coupled receptor	0.006	0.1119	0.1119
Brugia malayi	Dopamine receptor protein 1	0.006	0.1119	0.1119
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.259	0.7561
Onchocerca volvulus		0.006	0.1119	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	opsin-like receptor	0.006	0.1119	0.1119
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0138	0.3426	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Leishmania major	hypothetical protein, conserved	0.0114	0.2714	0.7923
Brugia malayi	follicle stimulating hormone receptor	0.006	0.1119	0.1119
Schistosoma mansoni	amine GPCR	0.006	0.1119	0.1119
Echinococcus granulosus	g protein coupled receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	neuropeptide Y receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Schistosoma mansoni	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	allatostatin A receptor	0.006	0.1119	0.1119
Schistosoma mansoni	neuropeptide F-like receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.006	0.1119	0.1119
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0138	0.3426	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0361	1	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.006	0.1119	0.1119
Echinococcus granulosus	7tm_1 domain containing protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	G protein-coupled receptor	0.006	0.1119	0.1119
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.006	0.1119	0.1119
Brugia malayi	G-protein coupled receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.006	0.1119	0.1119
Echinococcus multilocularis	neuropeptide receptor	0.006	0.1119	0.1119
Schistosoma mansoni	adenoreceptor	0.006	0.1119	0.1119
Echinococcus multilocularis	neuropeptide receptor A26	0.006	0.1119	0.1119
Schistosoma mansoni	neuropeptide receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	orexin receptor type 2	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.006	0.1119	0.1119
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Schistosoma mansoni	histamine h1 receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.006	0.1119	0.1119
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.006	0.1119	0.1119
Echinococcus granulosus	somatostatin receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Loa Loa (eye worm)	neuropeptide F receptor	0.006	0.1119	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	neuropeptides capa receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	serotonin receptor	0.006	0.1119	0.1119
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0138	0.3426	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.006	0.1119	0.1119
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.006	0.1119	0.1119
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0361	1	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	Melatonin receptor type 1A	0.006	0.1119	0.1119
Echinococcus granulosus	dihydrofolate reductase	0.0361	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.1119	0.1119
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.1119	0.1119
Schistosoma mansoni	dihydrofolate reductase	0.0361	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.006	0.1119	0.1119
Schistosoma mansoni	amine GPCR	0.006	0.1119	0.1119
Schistosoma mansoni	neuropeptide F-like receptor	0.006	0.1119	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Echinococcus granulosus	neuropeptide receptor	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Echinococcus granulosus	neuropeptide receptor	0.006	0.1119	0.1119
Schistosoma mansoni	neuropeptide f receptor 76f	0.006	0.1119	0.1119
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0	0.5
Brugia malayi	neuropeptide F receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.1119	0.1119
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.1119	0.1119
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Echinococcus multilocularis	g protein coupled receptor	0.006	0.1119	0.1119
Schistosoma mansoni	biogenic amine receptor	0.006	0.1119	0.1119
Chlamydia trachomatis	dihydrofolate reductase	0.0361	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	neuropeptides capa receptor	0.006	0.1119	0.1119
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	neuropeptide receptor	0.006	0.1119	0.1119
Brugia malayi	putative neuropeptide receptor	0.006	0.1119	0.1119
Brugia malayi	Dopamine receptor protein 2	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Brugia malayi	RE15519p	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	neuropeptide FF receptor 2	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Echinococcus multilocularis	g protein coupled receptor	0.006	0.1119	0.1119
Echinococcus granulosus	alpha 1A adrenergic receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	fmrfamide receptor	0.006	0.1119	0.1119
Brugia malayi	Tachykinin-like peptides receptor 99D	0.006	0.1119	0.1119
Echinococcus multilocularis	serotonin receptor	0.006	0.1119	0.1119
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.006	0.1119	0.1119
Echinococcus granulosus	neuropeptide FF receptor 2	0.006	0.1119	0.1119
Schistosoma mansoni	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	neuropeptide receptor	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Echinococcus granulosus	g-protein coupled receptor	0.006	0.1119	0.1119
Echinococcus granulosus	dro:myosuppressin receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	somatostatin receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Echinococcus granulosus	orexin receptor type 2	0.006	0.1119	0.1119
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0313	0.8604	0.8604
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Brugia malayi	ORL1-like opioid receptor	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Schistosoma mansoni	opsin-like receptor	0.006	0.1119	0.1119
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.006	0.1119	0.1119
Echinococcus multilocularis	neuropeptides capa receptor	0.006	0.1119	0.1119
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Echinococcus multilocularis	fmrfamide receptor	0.006	0.1119	0.1119
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.006	0.1119	0.1119
Brugia malayi	G protein-coupled receptor F59B2.13	0.006	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.006	0.1119	0.1119
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.006	0.1119	0.1119
Schistosoma mansoni	biogenic amine (5HT) receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	neuropeptide F receptor	0.006	0.1119	0.1119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.006	0.1119	0.1119
Brugia malayi	hypothetical protein	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Brugia malayi	larval opioid receptor	0.006	0.1119	0.1119
Brugia malayi	G-protein coupled receptor	0.006	0.1119	0.1119
Echinococcus granulosus	neuropeptide receptor A26	0.006	0.1119	0.1119
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	0.8604	0.8604
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.006	0.1119	0.1119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.1119	0.1119
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.006	0.1119	0.1119
Onchocerca volvulus		0.006	0.1119	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.006	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.1119

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 9.3 %	Inhibition of DNA-PK in HeLa cell nuclear extracts at 1.0 uM	ChEMBL.	17371003
Inhibition (binding)	= 9.3 %	Inhibition of DNA-PK in HeLa cell nuclear extracts at 1.0 uM	ChEMBL.	17371003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 16203600

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 417345