TDR Targets

Basic information

Technical information

TDR Targets ID: 417448
Name: methyl 2-(6-morpholin-4-yl-4-oxopyran-2-yl)be nzoate
MW: 315.321 | Formula: C17H17NO5
H donors: 0 H acceptors: 2 LogP: 1.57 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1ccccc1c1cc(=O)cc(o1)N1CCOCC1
InChi: 1S/C17H17NO5/c1-21-17(20)14-5-3-2-4-13(14)15-10-12(19)11-16(23-15)18-6-8-22-9-7-18/h2-5,10-11H,6-9H2,1H3
InChiKey: NOHUBHMKBHQSCG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl 2-(6-morpholino-4-oxo-pyran-2-yl)benzoate
2-(6-morpholino-4-oxo-2-pyranyl)benzoic acid methyl ester
methyl 2-(6-morpholin-4-yl-4-oxo-pyran-2-yl)benzoate
2-(4-keto-6-morpholino-pyran-2-yl)benzoic acid methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0603	0.2236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Schistosoma mansoni	opsin-like receptor	0.0049	0.0842	0.2555
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0042	0.0603	0.1831
Onchocerca volvulus		0.0049	0.0842	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus granulosus	7TM GPCR rhodopsin	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0096	0.2447	0.8303
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	voltage-gated potassium channel	0.0121	0.3295	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.065	0.224
Loa Loa (eye worm)	G-protein coupled receptor	0.0049	0.0842	0.2857
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.065	0.2205
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0842	0.2555
Echinococcus granulosus	hypothetical protein	0.0049	0.0842	0.0842
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Echinococcus multilocularis	dro:myosuppressin receptor	0.0049	0.0842	0.0842
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0842	0.2555
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0111	0.2947	0.2947
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.065	0.065
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Onchocerca volvulus		0.0049	0.0842	0.5
Trypanosoma cruzi	target of rapamycin kinase 3	0.0044	0.065	0.224
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0034	0.0317	0.1091
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0842	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.0842	0.0842
Brugia malayi	G protein-coupled receptor F59B2.13	0.0049	0.0842	0.2857
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0049	0.0842	0.2857
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0044	0.065	0.224
Echinococcus multilocularis	somatostatin receptor	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Brugia malayi	Melatonin receptor type 1A	0.0049	0.0842	0.2857
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0042	0.0603	0.208
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Brugia malayi	Dopamine receptor protein 1	0.0049	0.0842	0.2857
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Brugia malayi	larval opioid receptor	0.0049	0.0842	0.2857
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0049	0.0842	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0049	0.0842	0.2857
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0049	0.0842	0.2857
Schistosoma mansoni	hypothetical protein	0.0049	0.0842	0.2555
Schistosoma mansoni	histamine h1 receptor	0.0049	0.0842	0.2555
Schistosoma mansoni	amine GPCR	0.0049	0.0842	0.2555
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0032	0.0257	0.0871
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0842	0.2555
Schistosoma mansoni	adenoreceptor	0.0049	0.0842	0.2555
Schistosoma mansoni	neuropeptide f receptor 76f	0.0049	0.0842	0.2555
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0096	0.0356
Echinococcus multilocularis	serotonin receptor	0.0049	0.0842	0.0842
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0044	0.065	0.1913
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0096	0.0326
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.2901	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Brugia malayi	Dopamine receptor	0.0049	0.0842	0.2857
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Onchocerca volvulus		0.0049	0.0842	0.5
Schistosoma mansoni	hypothetical protein	0.0049	0.0842	0.2555
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0032	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0049	0.0842	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0842	0.0842
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus granulosus	neuropeptide receptor A26	0.0049	0.0842	0.0842
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0042	0.0603	0.9159
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.065	0.1913
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Echinococcus multilocularis	serotonin receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.065	0.2205
Leishmania major	hypothetical protein, conserved	0.0118	0.3188	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0842	0.2555
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0049	0.0842	0.0842
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0842	0.0842
Echinococcus granulosus	G protein coupled receptor 139	0.0049	0.0842	0.0842
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0049	0.0842	0.0842
Onchocerca volvulus		0.0049	0.0842	0.5
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0842	0.0842
Echinococcus granulosus	fmrfamide receptor	0.0049	0.0842	0.0842
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.065	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Brugia malayi	Serotonin receptor	0.0049	0.0842	0.2857
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0049	0.0842	0.2555
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0044	0.065	0.065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Onchocerca volvulus		0.0049	0.0842	0.5
Schistosoma mansoni	myosin xvIII	0.0049	0.0842	0.2555
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0257	0.0779
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Onchocerca volvulus		0.0049	0.0842	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	opsin-like receptor	0.0049	0.0842	0.2555
Brugia malayi	Dopamine receptor protein 2	0.0049	0.0842	0.2857
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0842	0.0842
Onchocerca volvulus		0.0049	0.0842	0.5
Brugia malayi	G-protein coupled receptor	0.0049	0.0842	0.2857
Echinococcus multilocularis	orexin receptor type 2	0.0049	0.0842	0.0842
Onchocerca volvulus		0.0049	0.0842	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0032	0.0257	0.0257
Brugia malayi	ORL1-like opioid receptor	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0049	0.0842	0.0842
Onchocerca volvulus		0.0049	0.0842	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0049	0.0842	0.0842
Echinococcus granulosus	orexin receptor type 2	0.0049	0.0842	0.0842
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0257	0.0779
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.0049	0.017
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0049	0.0842	0.0842
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Onchocerca volvulus		0.0049	0.0842	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0049	0.0842	0.2555
Onchocerca volvulus		0.0049	0.0842	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0049	0.0842	0.2555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0111	0.2947	0.2947
Echinococcus granulosus	somatostatin receptor	0.0049	0.0842	0.0842
Echinococcus multilocularis	neuropeptide s receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	G-protein coupled receptor	0.0049	0.0842	0.2857
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0049	0.0842	0.2555
Brugia malayi	neuropeptide F receptor	0.0049	0.0842	0.2857
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.0842	0.0842
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0042	0.0603	0.2047
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.065	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.065	1
Echinococcus granulosus	neuropeptide receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Onchocerca volvulus		0.0049	0.0842	0.5
Onchocerca volvulus		0.0049	0.0842	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0049	0.0842	0.0842
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0044	0.065	1
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Loa Loa (eye worm)	neuropeptide F receptor	0.0049	0.0842	0.2857
Brugia malayi	GnHR receptor homolog	0.0049	0.0842	0.2857
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.065	0.224
Toxoplasma gondii	FATC domain-containing protein	0.0042	0.0603	0.9159
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0044	0.065	0.1913
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0044	0.065	0.1913
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0317	0.1074
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0842	0.0842
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0842	0.2555
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0049	0.0842	0.2555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.0842	0.0842
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0842	0.2555
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Entamoeba histolytica	hypothetical protein	0.0042	0.0603	0.9283
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.0842	0.0842
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.065	0.1972
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0842	0.2555
Brugia malayi	AKH receptor	0.0049	0.0842	0.2857
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0049	0.0842	0.2857
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.065	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0049	0.0842	0.2555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.0842	0.0842
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0044	0.065	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus multilocularis	sex peptide receptor	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus granulosus	voltage gated potassium channel	0.0032	0.0257	0.0257
Onchocerca volvulus		0.0049	0.0842	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.0842	0.0842
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0049	0.0842	0.0842
Brugia malayi	G protein-coupled receptor	0.0049	0.0842	0.2857
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0842	0.0842
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.0842	0.0842
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0049	0.0842	0.0842
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Brugia malayi	follicle stimulating hormone receptor	0.0049	0.0842	0.2857
Echinococcus multilocularis	voltage gated potassium channel	0.0032	0.0257	0.0257
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.2698	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0044	0.065	0.1972
Loa Loa (eye worm)	melatonin receptor type 1A	0.0049	0.0842	0.2857
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0044	0.065	0.224
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Echinococcus multilocularis	g-protein coupled receptor	0.0049	0.0842	0.0842
Onchocerca volvulus		0.0049	0.0842	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0049	0.0842	0.2555
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0049	0.0842	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus granulosus	serotonin receptor	0.0049	0.0842	0.0842
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.2698	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Onchocerca volvulus		0.0049	0.0842	0.5
Brugia malayi	RE15519p	0.0049	0.0842	0.2857
Schistosoma mansoni	hypothetical protein	0.0049	0.0842	0.2555
Onchocerca volvulus		0.0049	0.0842	0.5
Brugia malayi	G-protein coupled receptor	0.0049	0.0842	0.2857
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.0842	0.0842
Schistosoma mansoni	amine GPCR	0.0049	0.0842	0.2555
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0257	0.0871
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0842	0.2555
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0044	0.065	0.065
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0049	0.0842	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus granulosus	sex peptide receptor	0.0049	0.0842	0.0842
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0049	0.0842	0.2555
Loa Loa (eye worm)	TYRA-2 protein	0.0049	0.0842	0.2857
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0049	0.0842	0.2555
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0842	0.0842
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0842	0.0842
Echinococcus granulosus	dro:myosuppressin receptor	0.0049	0.0842	0.0842
Echinococcus multilocularis	allatostatin A receptor	0.0049	0.0842	0.0842
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0044	0.065	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	hypothetical protein	0.0049	0.0842	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Brugia malayi	Serotonin receptor	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus granulosus	neuropeptide receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Giardia lamblia	GTOR	0.0044	0.065	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.0842	0.0842
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0049	0.0842	0.2857
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0318	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.0842	0.0842
Schistosoma mansoni	opsin-like receptor	0.0049	0.0842	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus granulosus	serine protein kinase ATM	0.0042	0.0603	0.0603
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.065	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0049	0.0842	0.2857
Brugia malayi	sulfakinin receptor protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.0842	0.0842
Brugia malayi	putative neuropeptide receptor	0.0049	0.0842	0.2857
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0049	0.0842	0.5
Brugia malayi	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Schistosoma mansoni	amine GPCR	0.0049	0.0842	0.2555
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0049	0.0842	0.2555
Echinococcus granulosus	allatostatin A receptor	0.0049	0.0842	0.0842
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.065	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0049	0.0842	0.0842
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.065	0.1913
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0049	0.0842	0.2555
Schistosoma mansoni	amine GPCR	0.0049	0.0842	0.2555
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0049	0.0842	0.2857
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0096	0.0356
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0111	0.2947	1
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0842	0.2555
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0049	0.0842	0.0842
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0842	0.0842
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0049	0.0842	0.2555
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.0842	0.0842
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0044	0.065	1
Schistosoma mansoni	voltage-gated potassium channel	0.0121	0.3295	1
Echinococcus granulosus	g-protein coupled receptor	0.0049	0.0842	0.0842
Echinococcus granulosus	neuropeptide FF receptor 2	0.0049	0.0842	0.0842
Loa Loa (eye worm)	neuropeptide F receptor	0.0049	0.0842	0.2857
Echinococcus granulosus	neuropeptide s receptor	0.0049	0.0842	0.0842
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0111	0.2947	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.065	0.065
Schistosoma mansoni	amine GPCR	0.0049	0.0842	0.2555
Schistosoma mansoni	growth hormone secretagogue receptor	0.0049	0.0842	0.2555
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0842	0.2555
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0049	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0842	0.2857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0049	0.0842	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.065	0.2409
Echinococcus multilocularis	serine protein kinase ATM	0.0042	0.0603	0.0603
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.0842	0.0842
Brugia malayi	neuropeptide F receptor	0.0049	0.0842	0.2857

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10 uM	Inhibition of ATM kinase	ChEMBL.	17371003
IC50 (binding)	> 10 uM	Inhibition of ATM kinase	ChEMBL.	17371003
IC50 (binding)	= 19 uM	Inhibition of DNA-PK in HeLa cell nuclear extracts	ChEMBL.	17371003
IC50 (binding)	= 19 uM	Inhibition of DNA-PK in HeLa cell nuclear extracts	ChEMBL.	17371003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL373526
PubChem: 16203591

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 417448