Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth hormone secretagogue receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | rhodopsin-like orphan GPCR | growth hormone secretagogue receptor | 289 aa | 243 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0177 | 0.5 | 0.5 |
Brugia malayi | Degenerin mec-4 | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | sodium channel nonvoltage gated 1 alpha | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | amiloride sensitive cation channel acid sensing ion channel pituitary | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | protein vprbp | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0177 | 0.5 | 0.5 |
Brugia malayi | amiloride-sensitive sodium channel alpha-subunit, putative | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Brugia malayi | Degenerin-like protein C41C4.5 in chromosome II, putative | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0177 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0.5 | 0.5 | |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | protein vprbp | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | degenerin unc-8 | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | acid sensing ion channel 4 pituitary | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Brugia malayi | Amiloride-sensitive sodium channel family protein | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | sodium channel nonvoltage gated 1 alpha | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | FMRFamide-gated Na+ channel | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | amiloride sensitive cation channel | 0.0177 | 0.5 | 0.5 |
Brugia malayi | Degenerin unc-8 | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | amiloride sensitive sodium channel | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0177 | 0.5 | 0.5 |
Brugia malayi | Amiloride-sensitive sodium channel family protein | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization | ChEMBL. | 17375904 |
Activity (functional) | = 29 % | Activity at human GHS1a receptor expressed in CHO cells assessed as intracellular calcium mobilization relative to 0.1 uM ghrelin | ChEMBL. | 17375904 |
Activity (functional) | = 29 % | Activity at human GHS1a receptor expressed in CHO cells assessed as intracellular calcium mobilization relative to 0.1 uM ghrelin | ChEMBL. | 17375904 |
IC50 (binding) | = 110 nM | Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells | ChEMBL. | 17375904 |
IC50 (binding) | = 110 nM | Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells | ChEMBL. | 17375904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.