Detailed information for compound 418318

Basic information

Technical information
  • TDR Targets ID: 418318
  • Name: 2-(1-benzothiophen-2-yl)-6-morpholin-4-ylpyra n-4-one
  • MW: 313.371 | Formula: C17H15NO3S
  • H donors: 0 H acceptors: 1 LogP: 2.77 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(oc(c1)c1cc2c(s1)cccc2)N1CCOCC1
  • InChi: 1S/C17H15NO3S/c19-13-10-14(16-9-12-3-1-2-4-15(12)22-16)21-17(11-13)18-5-7-20-8-6-18/h1-4,9-11H,5-8H2
  • InChiKey: PNTHQTGJVXEBNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(benzothiophen-2-yl)-6-morpholino-pyran-4-one
  • 2-(2-benzothiophenyl)-6-morpholino-4-pyranone
  • 2-(1-benzothiophen-2-yl)-6-morpholin-4-yl-pyran-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, DNA-activated, catalytic polypeptide Starlite/ChEMBL References
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0559 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.0975 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0975 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Schistosoma mansoni adenoreceptor 0.0056 0.0975 1
Schistosoma mansoni biogenic amine receptor 0.0056 0.0975 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0975 0.0488
Schistosoma mansoni neuropeptide receptor 0.0056 0.0975 1
Echinococcus granulosus somatostatin receptor 0.0056 0.0975 0.0488
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0975 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0975 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0044 0.0559 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0975 0.0488
Brugia malayi Serotonin receptor 0.0056 0.0975 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0975 1
Schistosoma mansoni histamine h1 receptor 0.0056 0.0975 1
Brugia malayi Dopamine receptor protein 2 0.0056 0.0975 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0975 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0044 0.0559 0.129
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0044 0.0559 0.129
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0975 0.0488
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.2832 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0975 0.0488
Echinococcus granulosus allatostatin A receptor 0.0056 0.0975 0.0488
Brugia malayi Dopamine receptor protein 1 0.0056 0.0975 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0318 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0559 0.129
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0975 1
Brugia malayi neuropeptide F receptor 0.0056 0.0975 1
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0975 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0975 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0559 1
Echinococcus granulosus orexin receptor type 2 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus granulosus neuropeptide receptor 0.0056 0.0975 0.0488
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0975 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Schistosoma mansoni amine GPCR 0.0056 0.0975 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0975 1
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0975 0.0488
Brugia malayi Serotonin receptor 0.0056 0.0975 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0044 0.0559 0.1015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0975 0.0488
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0975 0.0488
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0975 1
Brugia malayi hypothetical protein 0.0056 0.0975 1
Brugia malayi ORL1-like opioid receptor 0.0056 0.0975 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0559 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0975 1
Onchocerca volvulus 0.0056 0.0975 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0975 0.5
Schistosoma mansoni biogenic amine receptor 0.0056 0.0975 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0975 0.0488
Brugia malayi follicle stimulating hormone receptor 0.0056 0.0975 1
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Brugia malayi hypothetical protein 0.0056 0.0975 1
Onchocerca volvulus 0.0056 0.0975 0.5
Schistosoma mansoni biogenic amine receptor 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Brugia malayi Melatonin receptor type 1A 0.0056 0.0975 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0044 0.0559 0.129
Brugia malayi hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0975 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0975 1
Schistosoma mansoni myosin xvIII 0.0056 0.0975 1
Schistosoma mansoni neuropeptide receptor 0.0056 0.0975 1
Brugia malayi hypothetical protein 0.0056 0.0975 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0044 0.0559 0.005
Schistosoma mansoni opsin-like receptor 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus granulosus sex peptide receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0034 0.0223 0.2283
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0975 0.0488
Brugia malayi hypothetical protein 0.0056 0.0975 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0559 1
Brugia malayi GnHR receptor homolog 0.0056 0.0975 1
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0975 0.0488
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0975 0.0488
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0975 0.0488
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0975 0.0488
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0975 0.0488
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0975 0.0488
Onchocerca volvulus 0.0056 0.0975 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0975 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0975 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0975 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0975 0.0488
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0559 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0975 0.0488
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0975 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0975 1
Echinococcus granulosus g protein coupled receptor 0.0056 0.0975 0.0488
Onchocerca volvulus 0.0056 0.0975 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0975 1
Onchocerca volvulus 0.0056 0.0975 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0042 0.0512 0.9159
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0975 0.0488
Toxoplasma gondii target of rapamycin (TOR), putative 0.0044 0.0559 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0975 0.0488
Brugia malayi neuropeptide F receptor 0.0056 0.0975 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Brugia malayi putative neuropeptide receptor 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0975 0.0488
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Brugia malayi hypothetical protein 0.0056 0.0975 1
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0975 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Schistosoma mansoni hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Schistosoma mansoni opsin-like receptor 0.0056 0.0975 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0975 1
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0975 0.0488
Onchocerca volvulus 0.0056 0.0975 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Onchocerca volvulus 0.0056 0.0975 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Onchocerca volvulus 0.0056 0.0975 0.5
Brugia malayi hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0044 0.0559 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0975 0.0488
Onchocerca volvulus 0.0056 0.0975 0.5
Schistosoma mansoni amine GPCR 0.0056 0.0975 1
Onchocerca volvulus 0.0056 0.0975 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0975 0.0488
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0975 1
Giardia lamblia GTOR 0.0044 0.0559 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0975 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0975 0.0488
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0975 0.0488
Brugia malayi larval opioid receptor 0.0056 0.0975 1
Schistosoma mansoni neuropeptide receptor 0.0056 0.0975 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0975 1
Echinococcus granulosus g protein coupled receptor 0.0056 0.0975 0.0488
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0559 0.005
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0044 0.0559 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus granulosus serotonin receptor 0.0056 0.0975 0.0488
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0975 0.0488
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0975 0.0488
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0975 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0975 1
Echinococcus multilocularis sex peptide receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Brugia malayi RE15519p 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0975 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0559 0.005
Onchocerca volvulus 0.0056 0.0975 0.5
Brugia malayi sulfakinin receptor protein 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0975 0.0488
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0975 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0975 0.0488
Echinococcus multilocularis somatostatin receptor 0.0056 0.0975 0.0488
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0975 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0975 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0044 0.0559 0.005
Brugia malayi G protein-coupled receptor 0.0056 0.0975 1
Schistosoma mansoni hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0975 0.0488
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0975 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0975 0.0488
Echinococcus multilocularis serotonin receptor 0.0056 0.0975 0.0488
Onchocerca volvulus 0.0056 0.0975 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0975 0.0488
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0975 0.0488
Brugia malayi Dopamine receptor 0.0056 0.0975 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0975 1
Onchocerca volvulus 0.0056 0.0975 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Onchocerca volvulus 0.0056 0.0975 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0975 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Echinococcus granulosus fmrfamide receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0512 0.9159
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0975 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0975 0.0488
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0975 0.0488
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0975 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0975 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Brugia malayi AKH receptor 0.0056 0.0975 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0975 1
Echinococcus granulosus neuropeptide receptor 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0975 0.0488
Echinococcus granulosus hypothetical protein 0.0056 0.0975 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Schistosoma mansoni hypothetical protein 0.0056 0.0975 1
Toxoplasma gondii FATC domain-containing protein 0.0042 0.0512 0.9159
Onchocerca volvulus 0.0056 0.0975 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0975 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0975 0.0488
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0512 0.111
Onchocerca volvulus 0.0056 0.0975 0.5
Schistosoma mansoni hypothetical protein 0.0056 0.0975 1
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0975 0.0488
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Schistosoma mansoni opsin-like receptor 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Schistosoma mansoni neuropeptide receptor 0.0056 0.0975 1
Echinococcus granulosus g protein coupled receptor 0.0056 0.0975 0.0488
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0559 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Schistosoma mansoni amine GPCR 0.0056 0.0975 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0975 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0559 0.129
Leishmania major hypothetical protein, conserved 0.0118 0.3121 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0975 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0975 0.0488
Schistosoma mansoni amine GPCR 0.0056 0.0975 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0975 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0559 0.5733
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0975 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0559 0.5733
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0975 1
Echinococcus multilocularis serotonin receptor 0.0056 0.0975 0.0488
Brugia malayi hypothetical protein 0.0056 0.0975 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0975 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0975 1
Brugia malayi hypothetical protein 0.0056 0.0975 1
Brugia malayi hypothetical protein 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Brugia malayi G-protein coupled receptor 0.0056 0.0975 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0975 0.0488
Brugia malayi G-protein coupled receptor 0.0056 0.0975 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0559 1
Schistosoma mansoni amine GPCR 0.0056 0.0975 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0975 1
Onchocerca volvulus 0.0056 0.0975 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0559 0.1015

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.6 uM Inhibition of DNA-PK in HeLa cell nuclear extracts ChEMBL. 17371003
IC50 (binding) = 0.6 uM Inhibition of DNA-PK in HeLa cell nuclear extracts ChEMBL. 17371003
IC50 (binding) > 10 uM Inhibition of ATM kinase ChEMBL. 17371003
IC50 (binding) > 10 uM Inhibition of ATM kinase ChEMBL. 17371003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.