Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Receptor protein-tyrosine kinase erbB-2 | Starlite/ChEMBL | References |
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0205 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.021 | 0.32 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0194 | 0.021 | 0.32 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.036 | 0.0637 | 0.0628 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0194 | 0.021 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.036 | 0.0637 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.036 | 0.0637 | 0.0628 |
Loa Loa (eye worm) | hypothetical protein | 0.4015 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0205 | 0.3117 |
Toxoplasma gondii | prostaglandin-E synthase | 0.4015 | 1 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.4015 | 1 | 0.5 |
Onchocerca volvulus | 0.4015 | 1 | 0.5 | |
Echinococcus multilocularis | insulin receptor | 0.0115 | 0.0009 | 0.0145 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0115 | 0.0009 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.036 | 0.0637 | 1 |
Trypanosoma brucei | Prostaglandin E synthase | 0.4015 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0194 | 0.021 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.036 | 0.0637 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0205 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.021 | 0.32 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.4015 | 1 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.4015 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.049 uM | Inhibition of rat Receptor protein-tyrosine kinase erbB2 | ChEMBL. | 11378364 |
IC50 (binding) | = 0.049 uM | Inhibition of rat Receptor protein-tyrosine kinase erbB2 | ChEMBL. | 11378364 |
IC50 (functional) | = 0.35 uM | Inhibition of c-erbB-2 overexpressing HB4a cell proliferation | ChEMBL. | 11378364 |
IC50 (functional) | = 0.35 uM | Inhibition of c-erbB-2 overexpressing HB4a cell proliferation | ChEMBL. | 11378364 |
Selectivity (binding) | = 12.5 | Selectivity for EGF recptor and c-erbB-2 | ChEMBL. | 11378364 |
Selectivity (binding) | = 12.5 | Selectivity for EGF recptor and c-erbB-2 | ChEMBL. | 11378364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.