Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | epidermal growth factor receptor | 0.0248 | 0.518 | 0.5133 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0459 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0459 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0318 | 0.6781 | 0.6781 |
Schistosoma mansoni | tyrosine kinase | 0.0243 | 0.5081 | 0.5081 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0248 | 0.518 | 0.5133 |
Schistosoma mansoni | tyrosine kinase | 0.0243 | 0.5081 | 0.5081 |
Echinococcus multilocularis | expressed protein | 0.0194 | 0.3966 | 0.3906 |
Plasmodium vivax | kinesin-5 | 0.002 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.2605 | 0.2605 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0026 | 0.0129 | 0.0032 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0318 | 0.6781 | 0.6781 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0248 | 0.518 | 0.5133 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.2912 | 0.2912 |
Schistosoma mansoni | nephrin | 0.0024 | 0.0097 | 0.0097 |
Echinococcus multilocularis | kinesin family 1 | 0.0155 | 0.3062 | 0.2994 |
Echinococcus multilocularis | roundabout 2 | 0.0031 | 0.0241 | 0.0145 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0459 | 1 | 1 |
Plasmodium falciparum | kinesin-5 | 0.002 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0459 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0148 | 0.2912 | 0.2842 |
Schistosoma mansoni | cell adhesion molecule | 0.0026 | 0.0129 | 0.0129 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0148 | 0.2912 | 0.2842 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0148 | 0.2912 | 0.2842 |
Entamoeba histolytica | kinesin, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0148 | 0.2912 | 0.2912 |
Brugia malayi | Protein kinase domain containing protein | 0.0148 | 0.2912 | 0.2912 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0241 | 0.0241 |
Echinococcus multilocularis | 0.0142 | 0.2767 | 0.2696 | |
Schistosoma mansoni | tyrosine kinase | 0.0248 | 0.518 | 0.518 |
Echinococcus granulosus | kinesin family 1 | 0.0155 | 0.3062 | 0.2994 |
Echinococcus granulosus | expressed protein | 0.0194 | 0.3966 | 0.3906 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0241 | 0.0241 |
Echinococcus granulosus | insulin receptor | 0.0148 | 0.2912 | 0.2842 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0297 | 0.6308 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0243 | 0.5081 | 0.5081 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.2912 | 0.2912 |
Echinococcus granulosus | roundabout 2 | 0.0031 | 0.0241 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0248 | 0.518 | 0.518 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0129 | 0.0129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 | Growth inhibition of human KB cells by MTT assay | ChEMBL. | 17049252 |
IC50 (functional) | 0 | Growth inhibition of human NCI-H460 cells by MTT assay | ChEMBL. | 17049252 |
IC50 (functional) | 0 | Growth inhibition of human HCT116 cells by MTT assay | ChEMBL. | 17049252 |
IC50 (functional) | 0 | Growth inhibition of human CCRF-HSB-2 cells by MTT assay | ChEMBL. | 17049252 |
IC50 (functional) | = 0.013 uM | Cytotoxicity against HL60 cells after 72 hrs by dye exclusion assay | ChEMBL. | 17069934 |
IC50 (functional) | = 0.05 uM | Growth inhibition of human A431 cells by MTT assay | ChEMBL. | 17049252 |
IC50 (functional) | = 0.14 uM | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method | ChEMBL. | 17622129 |
IC50 (functional) | = 0.36 uM | Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric method | ChEMBL. | 17622129 |
IC50 (functional) | = 0.5 uM | Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method | ChEMBL. | 17622129 |
IC50 (functional) | = 0.62 uM | Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method | ChEMBL. | 17622129 |
IC50 (functional) | = 0.74 uM | Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method | ChEMBL. | 17622129 |
IC50 (functional) | = 2 uM | Cytotoxicity against adriamycin-resistant HL60/ADR cells expressing MRP1 after 72 hrs by dye exclusion assay | ChEMBL. | 17069934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.