Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.6614 | 0.1027 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1828 | 0.1828 |
Brugia malayi | hypoxia-induced factor 1 | 0.0163 | 0.5424 | 0.5424 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0078 | 0.2103 | 0.7907 |
Onchocerca volvulus | 0.0257 | 0.9092 | 1 | |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.028 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0177 | 0.5961 | 0.5961 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.6614 | 0.1027 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0184 | 0.6226 | 0.6743 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2497 | 0.2497 |
Schistosoma mansoni | ets-related | 0.0238 | 0.8368 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0295 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1657 | 0.1657 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0053 | 0.1093 | 0.0989 |
Echinococcus granulosus | jun protein | 0.0091 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5961 | 0.5961 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1926 | 0.2021 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0163 | 0.5424 | 0.5424 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0438 | 0.0438 |
Brugia malayi | Pre-SET motif family protein | 0.0226 | 0.787 | 0.787 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0039 | 0.0556 | 1 |
Echinococcus multilocularis | jun protein | 0.0091 | 0.2595 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0251 | 0.8868 | 0.8868 |
Schistosoma mansoni | single-minded | 0.0053 | 0.1093 | 0.0989 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0295 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0091 | 0.2595 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0295 | 0.0295 |
Onchocerca volvulus | 0.0039 | 0.0556 | 0.0297 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0226 | 0.787 | 0.787 |
Brugia malayi | Fli-1 protein | 0.0238 | 0.8368 | 0.8368 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | gabp alpha | 0.0078 | 0.2103 | 0.224 |
Brugia malayi | bHLH-PAS transcription factor | 0.0039 | 0.0556 | 0.0556 |
Brugia malayi | Ets-domain containing protein | 0.0078 | 0.2103 | 0.2103 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0295 | 0.0295 |
Brugia malayi | Ets-domain containing protein | 0.0078 | 0.2103 | 0.2103 |
Trichomonas vaginalis | set domain proteins, putative | 0.0257 | 0.9092 | 0.7593 |
Schistosoma mansoni | jun-related protein | 0.0074 | 0.1926 | 0.2021 |
Onchocerca volvulus | 0.0071 | 0.1828 | 0.1743 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0078 | 0.2103 | 0.2103 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0039 | 0.0556 | 0.1137 |
Brugia malayi | PAS domain containing protein | 0.0053 | 0.1093 | 0.1093 |
Brugia malayi | bZIP transcription factor family protein | 0.0091 | 0.2595 | 0.2595 |
Brugia malayi | follicle stimulating hormone receptor | 0.0251 | 0.8868 | 0.8868 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.0438 | 0.0438 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0295 | 0.0199 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0078 | 0.2103 | 0.7864 |
Echinococcus granulosus | single minded 2 | 0.0039 | 0.0556 | 0.1313 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0091 | 0.2595 | 1 |
Loa Loa (eye worm) | fli-1 protein | 0.0238 | 0.8368 | 0.8368 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | = 91 % | In vivo Triglyceride lowering activity at a dose of 0.10 % of the diet | ChEMBL. | 6604818 |
Diet (functional) | = 100 % | In vivo sterol lowering activity at dose of 0.10 % of the diet | ChEMBL. | 6604818 |
Inhibition (binding) | < 71 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase | ChEMBL. | 6604818 |
Inhibition (binding) | < 71 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase | ChEMBL. | 6604818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.