Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0295 | 0.0295 |
Onchocerca volvulus | 0.0039 | 0.0556 | 0.0297 | |
Brugia malayi | Ets-domain containing protein | 0.0078 | 0.2103 | 0.2103 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0078 | 0.2103 | 0.7907 |
Loa Loa (eye worm) | fli-1 protein | 0.0238 | 0.8368 | 0.8368 |
Brugia malayi | Fli-1 protein | 0.0238 | 0.8368 | 0.8368 |
Echinococcus granulosus | jun protein | 0.0091 | 0.2595 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0295 | 0.5 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0078 | 0.2103 | 0.2103 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0295 | 0.0199 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.6614 | 0.1027 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0091 | 0.2595 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.6614 | 0.1027 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0091 | 0.2595 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0251 | 0.8868 | 0.8868 |
Brugia malayi | PAS domain containing protein | 0.0053 | 0.1093 | 0.1093 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0078 | 0.2103 | 0.7864 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.0438 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5961 | 0.5961 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1657 | 0.1657 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1828 | 0.1828 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Schistosoma mansoni | gabp alpha | 0.0078 | 0.2103 | 0.224 |
Echinococcus multilocularis | jun protein | 0.0091 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0295 | 0.0295 |
Schistosoma mansoni | single-minded | 0.0053 | 0.1093 | 0.0989 |
Brugia malayi | bZIP transcription factor family protein | 0.0091 | 0.2595 | 0.2595 |
Brugia malayi | bHLH-PAS transcription factor | 0.0039 | 0.0556 | 0.0556 |
Brugia malayi | hypoxia-induced factor 1 | 0.0163 | 0.5424 | 0.5424 |
Brugia malayi | hypothetical protein | 0.0177 | 0.5961 | 0.5961 |
Leishmania major | cytochrome p450-like protein | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0078 | 0.2103 | 0.2103 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Onchocerca volvulus | 0.0071 | 0.1828 | 0.1743 | |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0251 | 0.8868 | 0.8868 |
Echinococcus granulosus | single minded 2 | 0.0039 | 0.0556 | 0.1313 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0163 | 0.5424 | 0.5424 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0039 | 0.0556 | 0.1137 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0184 | 0.6226 | 0.6743 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1926 | 0.2021 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0039 | 0.0556 | 1 |
Schistosoma mansoni | jun-related protein | 0.0074 | 0.1926 | 0.2021 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0226 | 0.787 | 0.787 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2497 | 0.2497 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0053 | 0.1093 | 0.0989 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0438 | 0.0438 |
Schistosoma mansoni | ets-related | 0.0238 | 0.8368 | 1 |
Onchocerca volvulus | 0.0257 | 0.9092 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0226 | 0.787 | 0.787 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0295 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0257 | 0.9092 | 0.7593 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.028 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.028 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | = 91 % | In vivo Triglyceride lowering activity at a dose of 0.10 % of the diet | ChEMBL. | 6604818 |
Diet (functional) | = 100 % | In vivo sterol lowering activity at dose of 0.10 % of the diet | ChEMBL. | 6604818 |
Inhibition (binding) | < 71 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase | ChEMBL. | 6604818 |
Inhibition (binding) | < 71 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase | ChEMBL. | 6604818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.