Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0100701 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0671724 | 0.777427 | 0.777427 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0100701 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0835204 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0671724 | 0.777427 | 0.777427 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0671724 | 0.777427 | 0.777427 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0761582 | 0.899766 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0100701 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0671724 | 0.777427 | 0.777427 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0100701 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0835204 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0100701 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0835204 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0100701 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.9 ug ml-1 | Antiparasitic activity against Trypanosoma cruzei Y blood stream trypomastigotes | ChEMBL. | 17064907 |
IC50 (functional) | = 1.9 ug ml-1 | Antiparasitic activity against Trypanosoma cruzei Y blood stream trypomastigotes | ChEMBL. | 17064907 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 17064907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.