Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rho-associated, coiled-coil containing protein kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.0294 | 0.3438 | 1 |
Loa Loa (eye worm) | disintegrin family protein | 0.0216 | 0.1424 | 0.1424 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0946 | 0.0946 |
Brugia malayi | Disintegrin family protein | 0.0297 | 0.3524 | 0.3524 |
Brugia malayi | Hemopexin family protein | 0.0188 | 0.0688 | 0.0688 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0198 | 0.0946 | 0.0714 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0297 | 0.3524 | 0.3964 |
Loa Loa (eye worm) | matrixin family protein | 0.032 | 0.4126 | 0.4126 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0297 | 0.3524 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0481 | 0.8313 | 1 |
Onchocerca volvulus | 0.0188 | 0.0688 | 0.1036 | |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0546 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0294 | 0.3438 | 0.3438 |
Onchocerca volvulus | 0.0176 | 0.0379 | 0.0031 | |
Mycobacterium ulcerans | hydrolase | 0.0161 | 0 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0481 | 0.8313 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0161 | 0 | 0.5 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0297 | 0.3524 | 0.3964 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0194 | 0.0846 | 0.1483 |
Brugia malayi | Matrixin family protein | 0.032 | 0.4126 | 0.4126 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.0688 | 0.098 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0161 | 0 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0294 | 0.3438 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0198 | 0.0946 | 0.0714 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Inhibition of Rho kinase | ChEMBL. | 17046269 |
IC50 (binding) | = 10 nM | Inhibition of Rho kinase | ChEMBL. | 17046269 |
IC50 (functional) | = 1 uM | Inhibition of MCP1-induced cell migration in U937 cells expressing CCR2 by chemotaxis assay | ChEMBL. | 17046269 |
IC50 (functional) | = 1 uM | Inhibition of MCP1-induced cell migration in U937 cells expressing CCR2 by chemotaxis assay | ChEMBL. | 17046269 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.