Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ryanodine receptor 44f | 0.0559 | 0.1645 | 1 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0659 | 0.2962 | 0.5 |
Schistosoma mansoni | ryanodine receptor related | 0.0781 | 0.457 | 0.4331 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.2657 | 0.3809 |
Loa Loa (eye worm) | hypothetical protein | 0.0747 | 0.4113 | 0.9289 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0659 | 0.2962 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0448 | 0.0189 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0559 | 0.1645 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0972 | 0.7075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.4302 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | < 47 % | In vivo triglyceride lowering activity dosed at 0.10 % of the diet. | ChEMBL. | 6604817 |
Diet (functional) | < 71 % | In vivo sterol lowering activity at dose of 0.10 % of the diet | ChEMBL. | 6604817 |
Diet (functional) | < 77 % | In vivo sterol lowering activity when dosed as 0.03 % of the diet | ChEMBL. | 6604817 |
Diet (functional) | = 82 % | In vivo triglyceride lowering activity when dosed at 0.03 % of the diet | ChEMBL. | 6604817 |
Diet (functional) | < 85 % | In vivo sterol lowering activity when dosed as 0.01 % of the diet | ChEMBL. | 6604817 |
Diet (functional) | = 100 % | In vivo triglyceride lowering activity when dosed as 0.01 % of the diet | ChEMBL. | 6604817 |
Inhibition (binding) | = 0 % | In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase | ChEMBL. | 6604817 |
Inhibition (binding) | = 0 % | In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase | ChEMBL. | 6604817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.