Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0294 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0026 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0033 | 0.0251 | 0.5955 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0033 | 0.0251 | 0.5955 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0033 | 0.0251 | 0.5955 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0033 | 0.0251 | 0.5955 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0037 | 0.0386 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0026 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0033 | 0.0251 | 0.5955 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0033 | 0.0251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4673 | 0.4644 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1057 | 0.1008 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0033 | 0.0251 | 0.5955 |
Echinococcus granulosus | glutamate receptor 2 | 0.0033 | 0.0251 | 0.5955 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0033 | 0.0251 | 0.5955 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0037 | 0.0386 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0037 | 0.0386 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0033 | 0.0251 | 0.5955 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.1057 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0033 | 0.0251 | 0.5955 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 1 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0152 | 0.4673 | 0.4644 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1057 | 0.1008 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 10.3 ug ml-1 | Cytotoxicity against human HL60 cells after 48 hrs | ChEMBL. | 17432904 |
IC50 (ADMET) | = 10.3 ug ml-1 | Cytotoxicity against human HL60 cells after 48 hrs | ChEMBL. | 17432904 |
IC50 (ADMET) | = 29.7 ug ml-1 | Cytotoxicity against human SMMC7721 cells after 48 hrs | ChEMBL. | 17432904 |
IC50 (ADMET) | = 57.5 ug ml-1 | Cytotoxicity against human L02 cells after 48 hrs | ChEMBL. | 17432904 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17432904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.