Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0686 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0459 | 0.5337 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0686 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0459 | 0.5337 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0686 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0198 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0308 | 0.2238 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0686 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0686 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.026 | 0.1271 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0308 | 0.2238 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0459 | 0.5337 | 0.3992 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0686 | 1 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0459 | 0.5337 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0686 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0686 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0686 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0198 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0686 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0686 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 850 uM | Inhibition of VHR | ChEMBL. | 17394300 |
IC50 (binding) | = 850 uM | Inhibition of VHR | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of Yersinia pestis YopH expressed in Escherichia coli | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of HePTP | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of PTP1B | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of TCPTP | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of CD45 | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of HePTP | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of PTP1B | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of TCPTP | ChEMBL. | 17394300 |
IC50 (binding) | > 1000 uM | Inhibition of CD45 | ChEMBL. | 17394300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.