TDR Targets

Basic information

Technical information

TDR Targets ID: 423767
Name: 2-[2-(4-aminophenyl)pyridin-4-yl]-1,5,6,7-tet rahydropyrrolo[3,2-c]pyridin-4-one
MW: 304.346 | Formula: C18H16N4O
H donors: 3 H acceptors: 2 LogP: 1.63 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccc(cc1)c1nccc(c1)c1cc2c([nH]1)CCNC2=O
InChi: 1S/C18H16N4O/c19-13-3-1-11(2-4-13)16-9-12(5-7-20-16)17-10-14-15(22-17)6-8-21-18(14)23/h1-5,7,9-10,22H,6,8,19H2,(H,21,23)
InChiKey: OVFRSUMNMCYPAW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-(4-aminophenyl)-4-pyridyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase-activated protein kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Schistosoma japonicum	ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative	Get druggable targets OG5_131483	All targets in OG5_131483
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus multilocularis	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Brugia malayi	map kinase activated protein kinase protein 2	Get druggable targets OG5_131483	All targets in OG5_131483

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase-activated protein kinase 2	370 aa	303 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	beta tubulin	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Giardia lamblia	Beta tubulin	0.0257	1	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0257	1	0.5
Giardia lamblia	Beta tubulin	0.0257	1	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.0257	1	1
Echinococcus multilocularis	tubulin subunit beta	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0257	1	1
Schistosoma mansoni	tubulin subunit beta	0.0257	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Giardia lamblia	Beta tubulin	0.0257	1	0.5
Schistosoma mansoni	tubulin subunit beta	0.0257	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Echinococcus multilocularis	tubulin beta 1 chain	0.0257	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Echinococcus multilocularis	beta tubulin	0.0257	1	1
Brugia malayi	beta-tubulin, identical	0.0257	1	1
Trypanosoma brucei	beta tubulin	0.0257	1	0.5
Trypanosoma cruzi	beta tubulin, putative	0.0257	1	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0257	1	0.5
Trypanosoma brucei	beta tubulin	0.0257	1	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Schistosoma mansoni	tubulin subunit beta	0.0257	1	1
Toxoplasma gondii	beta tubulin	0.0257	1	0.5
Plasmodium vivax	tubulin beta chain, putative	0.0257	1	0.5
Trichomonas vaginalis	tubulin alpha chain, putative	0.0257	1	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.0257	1	1
Schistosoma mansoni	tubulin subunit beta	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Trichomonas vaginalis	tubulin, putative	0.0257	1	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0257	1	0.5
Schistosoma mansoni	tubulin subunit beta	0.0257	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0257	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0257	1	1
Trypanosoma brucei	beta tubulin	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Echinococcus multilocularis	Tubulin beta 2C chain	0.0257	1	1
Plasmodium falciparum	tubulin beta chain	0.0257	1	0.5
Entamoeba histolytica	tubulin family protein	0.0257	1	0.5
Echinococcus granulosus	tubulin subunit beta	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Toxoplasma gondii	beta-tubulin, putative	0.0257	1	0.5
Loa Loa (eye worm)	tubulin beta chain	0.0257	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0257	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0257	1	0.5
Echinococcus granulosus	tubulin beta 1 chain	0.0257	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0257	1	1
Echinococcus multilocularis	beta tubulin	0.0257	1	1
Leishmania major	beta tubulin	0.0257	1	0.5
Loa Loa (eye worm)	tubulin beta-4 chain	0.0257	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0257	1	1
Schistosoma mansoni	tubulin subunit beta	0.0257	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0257	1	1
Echinococcus granulosus	beta tubulin	0.0257	1	1
Loa Loa (eye worm)	beta-tubulin	0.0257	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0257	1	1
Trypanosoma brucei	beta tubulin	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Echinococcus granulosus	tubulin beta 4A class IVa	0.0257	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0257	1	0.5
Leishmania major	beta tubulin	0.0257	1	0.5
Entamoeba histolytica	tubulin family protein	0.0257	1	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.041 uM	Inhibition of MK2	ChEMBL.	17480064
IC50 (binding)	= 0.041 uM	Inhibition of MK2	ChEMBL.	17480064
IC50 (functional)	= 12 uM	Inhibition of TNFalpha production in U937 cells	ChEMBL.	17480064
IC50 (functional)	= 12 uM	Inhibition of TNFalpha production in U937 cells	ChEMBL.	17480064

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	17480064

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL226475
PubChem: 16720208

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 423767