TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 512.087 | Formula: C28H38ClN5O2
H donors: 1 H acceptors: 2 LogP: 3.06 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1ccccc1Cl)CN1CCN(CC1)C(=O)CCCCN1CCN(CC1)Cc1ccccc1
InChi: 1S/C28H38ClN5O2/c29-25-10-4-5-11-26(25)30-27(35)23-33-18-20-34(21-19-33)28(36)12-6-7-13-31-14-16-32(17-15-31)22-24-8-2-1-3-9-24/h1-5,8-11H,6-7,12-23H2,(H,30,35)
InChiKey: VPPAZWIJDJFUNJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	g-protein coupled receptor	0.0295	0.5518	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	tubulin beta chain	0.025	0.4576	0.4576
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.025	0.4576	0.8293
Loa Loa (eye worm)	LGC-31 protein	0.0052	0.0497	0.0497
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0052	0.0497	0.0497
Schistosoma mansoni	amine GPCR	0.0295	0.5518	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0052	0.0497	0.0497
Schistosoma mansoni	biogenic amine receptor	0.0295	0.5518	1
Onchocerca volvulus	Putative nachr subunit	0.0052	0.0497	0.0902
Brugia malayi	polk-prov protein	0.003	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Brugia malayi	1,4-alpha-glucan branching enzyme	0.0046	0.0377	0.0377
Schistosoma mansoni	hypothetical protein	0.0295	0.5518	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0295	0.5518	0.5518
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.5518	1
Chlamydia trachomatis	1,4-alpha-glucan branching enzyme	0.0046	0.0377	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0295	0.5518	1
Brugia malayi	Melatonin receptor type 1A	0.0295	0.5518	0.5518
Trichomonas vaginalis	amylase, putative	0.0046	0.0377	0.0313
Onchocerca volvulus		0.0295	0.5518	1
Onchocerca volvulus		0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0295	0.5518	1
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0241	0.0437
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Echinococcus granulosus	tm gpcr rhodopsin	0.0295	0.5518	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0052	0.0497	0.0497
Leishmania major	beta tubulin	0.025	0.4576	0.5
Trypanosoma brucei	beta tubulin	0.025	0.4576	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0295	0.5518	1
Schistosoma mansoni	neuropeptide receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Toxoplasma gondii	beta tubulin	0.025	0.4576	1
Schistosoma mansoni	hypothetical protein	0.0101	0.1496	0.2712
Schistosoma mansoni	neuropeptide receptor	0.0295	0.5518	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4576	0.8293
Echinococcus granulosus	g protein coupled receptor	0.0295	0.5518	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0295	0.5518	1
Schistosoma mansoni	biogenic amine receptor	0.0295	0.5518	1
Brugia malayi	putative neuropeptide receptor	0.0295	0.5518	0.5518
Trypanosoma brucei	beta tubulin	0.025	0.4576	1
Onchocerca volvulus		0.0295	0.5518	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0052	0.0497	0.0497
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0295	0.5518	1
Onchocerca volvulus		0.0295	0.5518	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.5518	1
Onchocerca volvulus		0.0295	0.5518	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0295	0.5518	1
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0052	0.0497	0.0902
Trichomonas vaginalis	starch branching enzyme II, putative	0.0046	0.0377	0.0313
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0295	0.5518	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0295	0.5518	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0497	0.0497
Echinococcus granulosus	neuropeptides capa receptor	0.0295	0.5518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Brugia malayi	sulfakinin receptor protein	0.0295	0.5518	0.5518
Toxoplasma gondii	beta-tubulin, putative	0.025	0.4576	1
Trypanosoma brucei	unspecified product	0.0033	0.0109	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	ACC-1 protein	0.0052	0.0497	0.0497
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0052	0.0497	0.0902
Echinococcus granulosus	neuropeptide FF receptor 2	0.0295	0.5518	1
Echinococcus granulosus	tubulin beta 1 chain	0.025	0.4576	0.8293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.5518	1
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0295	0.5518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Echinococcus granulosus	g protein coupled receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0295	0.5518	1
Schistosoma mansoni	biogenic amine receptor	0.0295	0.5518	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0295	0.5518	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4576	0.8293
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0295	0.5518	1
Brugia malayi	beta-tubulin, identical	0.025	0.4576	0.4576
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4576	0.8293
Loa Loa (eye worm)	BEN-1 protein	0.025	0.4576	0.4576
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0052	0.0497	0.0902
Echinococcus granulosus	dro:myosuppressin receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0052	0.0497	0.0497
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	g protein coupled receptor	0.0295	0.5518	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0295	0.5518	1
Schistosoma mansoni	opsin-like receptor	0.0295	0.5518	1
Mycobacterium ulcerans	glycogen branching protein	0.0046	0.0377	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0052	0.0497	0.0902
Loa Loa (eye worm)	TYRA-2 protein	0.0295	0.5518	0.5518
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0046	0.0377	0.0823
Echinococcus multilocularis	beta tubulin	0.025	0.4576	0.8293
Echinococcus granulosus	neuropeptides capa receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Brugia malayi	Dopamine receptor	0.0295	0.5518	0.5518
Leishmania major	beta tubulin	0.025	0.4576	0.5
Echinococcus granulosus	beta tubulin	0.025	0.4576	0.8293
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4576	0.8293
Echinococcus granulosus	serotonin receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.003	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Trichomonas vaginalis	alpha-amylase, putative	0.0104	0.1576	0.3079
Loa Loa (eye worm)	ACC-1 protein	0.0052	0.0497	0.0497
Echinococcus multilocularis	tubulin beta 1 chain	0.025	0.4576	0.8293
Brugia malayi	G protein-coupled receptor	0.0295	0.5518	0.5518
Brugia malayi	G-protein coupled receptor	0.0295	0.5518	0.5518
Brugia malayi	Cation transporter family protein	0.0052	0.0497	0.0497
Trichomonas vaginalis	amylase, putative	0.0104	0.1576	0.3079
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Echinococcus granulosus	hypothetical protein	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0512	1	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0052	0.0497	0.0497
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0295	0.5518	0.5518
Schistosoma mansoni	neuropeptide receptor	0.0295	0.5518	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0295	0.5518	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4576	0.8293
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Schistosoma mansoni	nAChR subunit	0.0052	0.0497	0.0902
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0295	0.5518	1
Schistosoma mansoni	nAChR subunit	0.0052	0.0497	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Onchocerca volvulus		0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0052	0.0497	0.0902
Echinococcus granulosus	tubulin beta 4A class IVa	0.025	0.4576	0.8293
Schistosoma mansoni	hypothetical protein	0.0295	0.5518	1
Echinococcus granulosus	glucan 14 alpha branching enzyme 1	0.0046	0.0377	0.0683
Echinococcus multilocularis	somatostatin receptor	0.0295	0.5518	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4576	0.8293
Onchocerca volvulus		0.0052	0.0497	0.0902
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus granulosus	biogenic amine 5HT receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	melatonin receptor type 1A	0.0295	0.5518	0.5518
Trichomonas vaginalis	tubulin gamma chain, putative	0.025	0.4576	1
Onchocerca volvulus		0.0052	0.0497	0.0902
Leishmania major	beta tubulin	0.025	0.4576	0.5
Giardia lamblia	Beta tubulin	0.025	0.4576	1
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0052	0.0497	0.0902
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0295	0.5518	1
Schistosoma mansoni	nAChR subunit	0.0052	0.0497	0.0902
Trichomonas vaginalis	alpha-amylase, putative	0.0104	0.1576	0.3079
Brugia malayi	Serotonin receptor	0.0295	0.5518	0.5518
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0052	0.0497	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Entamoeba histolytica	tubulin family protein	0.025	0.4576	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0052	0.0497	0.0902
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4576	0.8293
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	tubulin subunit beta	0.025	0.4576	0.8293
Echinococcus multilocularis	neuropeptide receptor	0.0295	0.5518	1
Echinococcus multilocularis	nAChR subunit	0.0052	0.0497	0.0902
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0295	0.5518	1
Schistosoma mansoni	nAChR subunit	0.0052	0.0497	0.0902
Leishmania major	beta tubulin	0.025	0.4576	0.5
Leishmania major	beta tubulin	0.025	0.4576	0.5
Schistosoma mansoni	amine GPCR	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Trichomonas vaginalis	alpha-amylase, putative	0.0093	0.134	0.2534
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	serotonin receptor	0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Onchocerca volvulus		0.0295	0.5518	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0295	0.5518	0.5518
Schistosoma mansoni	hypothetical protein	0.0295	0.5518	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0295	0.5518	0.5518
Echinococcus multilocularis	fmrfamide receptor	0.0295	0.5518	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0052	0.0497	0.0902
Schistosoma mansoni	nAChR subunit	0.0052	0.0497	0.0902
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0052	0.0497	0.0497
Echinococcus granulosus	allatostatin A receptor	0.0295	0.5518	1
Giardia lamblia	Beta tubulin	0.025	0.4576	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	glycine receptor subunit beta	0.0052	0.0497	0.0902
Schistosoma mansoni	myosin xvIII	0.0295	0.5518	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0295	0.5518	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4576	0.8293
Leishmania major	beta tubulin	0.025	0.4576	0.5
Plasmodium vivax	tubulin beta chain, putative	0.025	0.4576	0.5
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0052	0.0497	0.0497
Onchocerca volvulus		0.0052	0.0497	0.0902
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0052	0.0497	0.0902
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0497	0.0497
Brugia malayi	Dopamine receptor protein 2	0.0295	0.5518	0.5518
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Entamoeba histolytica	alpha-amylase family protein	0.0104	0.1576	0.3443
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Schistosoma mansoni	neuropeptide F-like receptor	0.0295	0.5518	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0497	0.0497
Echinococcus multilocularis	neuropeptide Y receptor	0.0295	0.5518	1
Schistosoma mansoni	amine GPCR	0.0295	0.5518	1
Entamoeba histolytica	tubulin family protein	0.025	0.4576	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0052	0.0497	0.0902
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0052	0.0497	0.0497
Onchocerca volvulus		0.0295	0.5518	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0295	0.5518	0.5518
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0295	0.5518	1
Schistosoma mansoni	histamine h1 receptor	0.0295	0.5518	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0295	0.5518	0.5518
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0241	0.0441
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.5518	1
Onchocerca volvulus		0.0295	0.5518	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0052	0.0497	0.0902
Brugia malayi	ORL1-like opioid receptor	0.0295	0.5518	0.5518
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0295	0.5518	1
Brugia malayi	Tubulin beta-1 chain	0.025	0.4576	0.4576
Schistosoma mansoni	neuropeptide receptor	0.0295	0.5518	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.025	0.4576	0.4576
Echinococcus granulosus	neuropeptide receptor	0.0295	0.5518	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0052	0.0497	0.0497
Onchocerca volvulus		0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0377	0.0377
Echinococcus multilocularis	glycine receptor subunit beta	0.0052	0.0497	0.0902
Loa Loa (eye worm)	tubulin beta-2A chain	0.025	0.4576	0.4576
Loa Loa (eye worm)	G-protein coupled receptor	0.0295	0.5518	0.5518
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0295	0.5518	1
Loa Loa (eye worm)	BEN-1 protein	0.025	0.4576	0.4576
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0052	0.0497	0.0497
Echinococcus granulosus	neuropeptide Y receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Trypanosoma brucei	beta tubulin	0.025	0.4576	1
Brugia malayi	G-protein coupled receptor	0.0295	0.5518	0.5518
Schistosoma mansoni	hypothetical protein	0.0295	0.5518	1
Toxoplasma gondii	beta-1 tubulin, putative	0.025	0.4576	1
Onchocerca volvulus		0.0295	0.5518	1
Echinococcus granulosus	tubulin subunit beta	0.025	0.4576	0.8293
Brugia malayi	RE15519p	0.0295	0.5518	0.5518
Echinococcus granulosus	sex peptide receptor	0.0295	0.5518	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0052	0.0497	0.0902
Echinococcus multilocularis	neuropeptide s receptor	0.0295	0.5518	1
Schistosoma mansoni	amine GPCR	0.0295	0.5518	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0295	0.5518	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.025	0.4576	1
Schistosoma mansoni	opsin-like receptor	0.0295	0.5518	1
Schistosoma mansoni	starch branching enzyme II	0.0046	0.0377	0.0683
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.5518	1
Brugia malayi	follicle stimulating hormone receptor	0.0295	0.5518	0.5518
Onchocerca volvulus		0.0052	0.0497	0.0902
Schistosoma mansoni	growth hormone secretagogue receptor	0.0295	0.5518	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0295	0.5518	0.5518
Trichomonas vaginalis	alpha-amylase, putative	0.0104	0.1576	0.3079
Brugia malayi	Cation transporter family protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Brugia malayi	neuropeptide F receptor	0.0295	0.5518	0.5518
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Brugia malayi	Serotonin receptor	0.0295	0.5518	0.5518
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0295	0.5518	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0052	0.0497	0.0902
Echinococcus granulosus	beta tubulin	0.025	0.4576	0.8293
Onchocerca volvulus		0.0295	0.5518	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	neuropeptide F receptor	0.0295	0.5518	0.5518
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.5518	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0295	0.5518	1
Echinococcus granulosus	neuropeptide Y receptor	0.0295	0.5518	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0052	0.0497	0.0902
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0046	0.0377	0.0823
Echinococcus multilocularis	g-protein coupled receptor	0.0295	0.5518	1
Echinococcus multilocularis	g protein coupled receptor	0.0295	0.5518	1
Schistosoma mansoni	opsin-like receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Echinococcus multilocularis	glucan (1,4 alpha), branching enzyme 1	0.0046	0.0377	0.0683
Echinococcus granulosus	glycine receptor subunit beta	0.0052	0.0497	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Trypanosoma brucei	RNA helicase, putative	0.0101	0.1496	0.3209
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4576	0.8293
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0052	0.0497	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Onchocerca volvulus		0.0295	0.5518	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0295	0.5518	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus granulosus	orexin receptor type 2	0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Onchocerca volvulus		0.0295	0.5518	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.5518	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Schistosoma mansoni	neuropeptide F-like receptor	0.0295	0.5518	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.025	0.4576	0.8293
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0052	0.0497	0.0497
Trichomonas vaginalis	tubulin beta chain, putative	0.025	0.4576	1
Schistosoma mansoni	nAChR subunit	0.0052	0.0497	0.0902
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Schistosoma mansoni	adenoreceptor	0.0295	0.5518	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0052	0.0497	0.0497
Leishmania major	beta tubulin	0.025	0.4576	0.5
Echinococcus multilocularis	beta tubulin	0.025	0.4576	0.8293
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0052	0.0497	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0295	0.5518	1
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4576	0.8293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Echinococcus granulosus	nAChR subunit	0.0052	0.0497	0.0902
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.5518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Echinococcus granulosus	fmrfamide receptor	0.0295	0.5518	1
Mycobacterium tuberculosis	1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme)	0.0046	0.0377	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Schistosoma mansoni	amine GPCR	0.0295	0.5518	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0295	0.5518	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0295	0.5518	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0295	0.5518	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0295	0.5518	0.5518
Echinococcus multilocularis	neuropeptides capa receptor	0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Trichomonas vaginalis	tubulin, putative	0.025	0.4576	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0295	0.5518	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.025	0.4576	1
Echinococcus multilocularis	g protein coupled receptor	0.0295	0.5518	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0295	0.5518	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4576	0.8293
Loa Loa (eye worm)	beta-tubulin	0.025	0.4576	0.4576
Trichomonas vaginalis	amylase, putative	0.0104	0.1576	0.3079
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0052	0.0497	0.0902
Echinococcus granulosus	glycine receptor subunit beta	0.0052	0.0497	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0052	0.0497	0.0902
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0295	0.5518	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0295	0.5518	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0052	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Schistosoma mansoni	tubulin subunit beta	0.025	0.4576	0.8293
Brugia malayi	Dopamine receptor protein 1	0.0295	0.5518	0.5518
Trypanosoma cruzi	beta tubulin, putative	0.025	0.4576	1
Echinococcus multilocularis	sex peptide receptor	0.0295	0.5518	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0052	0.0497	0.0497
Giardia lamblia	Beta tubulin	0.025	0.4576	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0295	0.5518	1
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus granulosus	Tubulin beta 2C chain	0.025	0.4576	0.8293
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Leishmania major	beta tubulin	0.025	0.4576	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.5518	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0295	0.5518	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0295	0.5518	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0295	0.5518	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0295	0.5518	0.5518
Echinococcus multilocularis	allatostatin A receptor	0.0295	0.5518	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0295	0.5518	1
Brugia malayi	larval opioid receptor	0.0295	0.5518	0.5518
Entamoeba histolytica	alpha-amylase family protein	0.0104	0.1576	0.3443
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0052	0.0497	0.0902
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0295	0.5518	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Echinococcus granulosus	neuropeptide receptor	0.0295	0.5518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Onchocerca volvulus		0.0052	0.0497	0.0902
Onchocerca volvulus		0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Brugia malayi	AKH receptor	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0052	0.0497	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0241	0.0441
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0052	0.0497	0.0902
Leishmania major	beta tubulin	0.025	0.4576	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0295	0.5518	0.5518
Onchocerca volvulus		0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.5518	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4576	0.8293
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0052	0.0497	0.0902
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0295	0.5518	0.5518
Echinococcus granulosus	rhodopsin orphan GPCR	0.0295	0.5518	1
Echinococcus multilocularis	orexin receptor type 2	0.0295	0.5518	1
Trichomonas vaginalis	alpha-amylase, putative	0.0104	0.1576	0.3079
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0052	0.0497	0.0902
Brugia malayi	neuropeptide F receptor	0.0295	0.5518	0.5518
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.5518	1
Onchocerca volvulus		0.0295	0.5518	1
Echinococcus multilocularis	serotonin receptor	0.0295	0.5518	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0033	0.0109	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0241	0.0441
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0052	0.0497	0.0902
Trichomonas vaginalis	tubulin epsilon chain, putative	0.025	0.4576	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	fmrfamide receptor	0.0295	0.5518	1
Schistosoma mansoni	tubulin subunit beta	0.025	0.4576	0.8293
Echinococcus granulosus	g protein coupled receptor	0.0295	0.5518	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0052	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Onchocerca volvulus		0.0052	0.0497	0.0902
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0295	0.5518	0.5518
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0052	0.0497	0.0902
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0295	0.5518	1
Brugia malayi	hypothetical protein	0.0295	0.5518	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0295	0.5518	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0052	0.0497	0.0902
Brugia malayi	GnHR receptor homolog	0.0295	0.5518	0.5518
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0295	0.5518	1
Plasmodium falciparum	tubulin beta chain	0.025	0.4576	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0295	0.5518	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.025	0.4576	0.4576
Loa Loa (eye worm)	neuropeptide F receptor	0.0295	0.5518	0.5518
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0295	0.5518	1
Echinococcus multilocularis	neuropeptide receptor	0.0295	0.5518	1
Echinococcus granulosus	neuropeptide s receptor	0.0295	0.5518	1
Leishmania major	beta tubulin	0.025	0.4576	0.5
Trypanosoma brucei	beta tubulin	0.025	0.4576	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0295	0.5518	1
Echinococcus granulosus	somatostatin receptor	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0497	0.0497
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0295	0.5518	0.5518
Brugia malayi	Cation transporter family protein	0.0052	0.0497	0.0497
Schistosoma mansoni	nAChR subunit	0.0052	0.0497	0.0902
Echinococcus granulosus	dna polymerase kappa	0.004	0.0241	0.0437
Echinococcus granulosus	neuropeptide receptor A26	0.0295	0.5518	1
Echinococcus granulosus	G protein coupled receptor 139	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518
Echinococcus multilocularis	neuropeptides capa receptor	0.0295	0.5518	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0295	0.5518	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.5518	0.5518

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 15.89 %	Inhibition of T type calcium channel subunit alpha1G expressed in HEK293 cells assessed as effect on KCl-induced increase in intracellular calcium level at 10 uM by FDSS assay	ChEMBL.	17150365
Inhibition (binding)	= 15.89 %	Inhibition of T type calcium channel subunit alpha1G expressed in HEK293 cells assessed as effect on KCl-induced increase in intracellular calcium level at 10 uM by FDSS assay	ChEMBL.	17150365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 424195