Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0124 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0124 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0124 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0044 | 0.3523 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0124 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0124 | 0.5 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.0876 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0124 | 0.008 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0124 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0124 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0124 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0124 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0124 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0044 | 0.3523 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0124 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0124 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0124 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0124 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0124 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0124 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0124 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0124 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0124 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0044 | 0.3523 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.0876 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 200 nM | Inhibition of Brucella suis histidinol dehydrogenase | ChEMBL. | 17481905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.