Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.0876 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0044 | 0.3523 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0124 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0124 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0124 | 0.008 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0124 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0124 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0124 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0124 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0124 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0124 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0124 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0124 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0124 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0124 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0124 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0044 | 0.3523 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.0876 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0124 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0124 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0044 | 0.3523 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0124 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0124 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0124 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0124 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14.5 nM | Inhibition of Brucella suis histidinol dehydrogenase | ChEMBL. | 17481905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.