Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GH02984p | 0.0135 | 0.0177 | 0.213 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0529 | 0.3735 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0135 | 0.0177 | 0.0439 |
Schistosoma mansoni | inositol transporter | 0.0529 | 0.3735 | 0.3621 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0177 | 0.1641 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0135 | 0.0177 | 0.5 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0222 | 0.0966 | 0.0803 |
Brugia malayi | sulfakinin receptor protein | 0.0207 | 0.0833 | 1 |
Onchocerca volvulus | 0.0135 | 0.0177 | 0.5 | |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0529 | 0.3735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.0833 | 0.7705 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0135 | 0.0177 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0039 | 0.0365 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0135 | 0.0177 | 0.0439 |
Echinococcus multilocularis | solute carrier family 5 | 0.0529 | 0.3735 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0135 | 0.0177 | 0.213 |
Echinococcus granulosus | solute carrier family 5 | 0.0529 | 0.3735 | 1 |
Schistosoma mansoni | inositol transporter | 0.0529 | 0.3735 | 0.3621 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0529 | 0.3735 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0529 | 0.3735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0177 | 0.1641 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0235 | 0.1081 | 1 |
Brugia malayi | hypothetical protein | 0.0207 | 0.0833 | 1 |
Schistosoma mansoni | integrin alpha | 0.0152 | 0.0335 | 0.0161 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0529 | 0.3735 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0135 | 0.0177 | 0.0439 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0152 | 0.0335 | 0.4027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate after 24 hrs | ChEMBL. | 17618124 |
MIC (functional) | = 6.25 ug ml-1 | Antifungal activity against Candida albicans ATCC 10145 after 48 hrs | ChEMBL. | 17618124 |
MIC (functional) | = 6.25 ug ml-1 | Antifungal activity against Candida albicans ATCC 10145 after 48 hrs | ChEMBL. | 17618124 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs | ChEMBL. | 17618124 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs | ChEMBL. | 17618124 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 23556 after 24 hrs | ChEMBL. | 17618124 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 23556 after 24 hrs | ChEMBL. | 17618124 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.